Antibiotic G418, a New Micrommomospora-produced Aminglycoside with Activity Apainst Protozoa and Helminths: Antiparasitic Activity

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1975 Jun 1

PMID 1155922

Citations 7

Authors

D Loebenberg

M Counels

J A Waitz

Affiliations

Soon will be listed here.

Abstract

Antibiotic G-418 was shown to be superior to paromomycin and metronidazole in cecal amoebiasis. Of particular interest was the high degree of activity seen with a relatively short treatment at low levels. Although the antibiotic was trichomonacidal in vitro at low levels, in vivo results indicated that at levels tested the antibiotic did not always affect cures. The antibiotic appears to have promise as an anticestode agent, being more active than paromomycin against Hymenolepis nana and active as a single oral dose at low levels against Taenia spp.

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References

Wagman G, Testa R, Marquez J, Weinstein M . Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization. Antimicrob Agents Chemother. 1974; 6(2):144-9. PMC: 444619. DOI: 10.1128/AAC.6.2.144. View

Waitz J, Sabatelli F, Menzel F, Moss Jr E . Biological activity of antibiotic G-418, a new micromonospora-produced aminoglycoside with activity against protozoa and helminths. Antimicrob Agents Chemother. 1974; 6(5):579-81. PMC: 444695. DOI: 10.1128/AAC.6.5.579. View

Thompson P, BAYLES A, HERBST S, OLSZEWSKI B, MEISENHELDER J . Antiamebic and antitrichomonal studies on the antibiotic paromomycin (humatin) in vitro and in experimental animals. Antibiot Chemother (Northfield). 1959; 9:618-26. View

Asami K . EFFECTS OF METRONIDAZOLE ON TRICHOMONAS VAGINALIS IN CULTURE AND IN AN EXPERIMENTAL HOST. Am J Trop Med Hyg. 1963; 12:535-8. DOI: 10.4269/ajtmh.1963.12.535. View

Jones W . Antibiotics in the treatment of amoebiasis. Nature. 1950; 165(4199):649. DOI: 10.1038/165649b0. View

Coffey G, Anderson L, Fisher M, GALBRAITH M, HILLEGAS A, KOHBERGER D . Biological studies of paromomycin. Antibiot Chemother (Northfield). 1959; 9:730-8. View

Albach R, SHAFFER J, Watson R . A comparison of in vitro drug sensitivities of strains of entamoeba which grow at 37 degrees C and at room temperature. Am J Trop Med Hyg. 1966; 15(6):855-9. DOI: 10.4269/ajtmh.1966.15.855. View

Cosar C, JULOU L . [The activity of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (R. P. 8823) against experimental Trichomonas vaginalis infections]. Ann Inst Pasteur (Paris). 1959; 96(2):238-41. View

Reeves R, MELENEY H, FRYE W . A modified Shaffer-Frye technique for the cultivation of Entamoeba histolytica and some observations on its carbohydrate requirements. Am J Hyg. 1957; 66(1):56-62. DOI: 10.1093/oxfordjournals.aje.a119885. View

10.

WILKINS J, HENSHAW C . The effect of endomycin and other antibiotics on Trichomonas vaginalis in vitro. Exp Parasitol. 1954; 3(5):417-24. DOI: 10.1016/0014-4894(54)90037-5. View

11.

CUCKLER A, MALANGA C, Conroy J . Therapeutic efficacy of new nitroimidazoles for experimental trichomoniasis, amebiasis, and trypanosomiasis. Am J Trop Med Hyg. 1970; 19(6):916-25. DOI: 10.4269/ajtmh.1970.19.916. View

12.

Powell S . New developments in the therapy of amoebiasis. Gut. 1970; 11(11):967-9. PMC: 1553132. View

13.

Waitz J, MCCLAY P, Thompson P . Effects of paromomycin on tapeworms of mice, rats, and cats. J Parasitol. 1966; 52(4):830-1. View

14.

DUREL P, ROIRON V, SIBOULET A, BOREL L . [Trial of an antitrichomonal drug derived from imidazole: RP-8823]. C R Soc Fr Gyncol. 1959; 29(1):36-45. View