» Articles » PMID: 11557319

Dexamethasone Attenuates Neutrophil Infiltration in the Rat Kidney in Ischemia/reperfusion Injury: the Possible Role of Nitroxyl

Overview
Date 2001 Sep 15
PMID 11557319
Citations 11
Authors
Affiliations
Soon will be listed here.
Abstract

Neutrophil infiltration to the tissue, which is one of the important pathogenetic factors in ischemia/reperfusion injury, can be inhibited by glucocorticoids. The purpose of the present study was to clarify the mechanisms by which glucocorticoids inhibit neutrophil infiltration in renal ischemia/reperfusion injury in rats. Pretreatment with dexamethasone significantly attenuated the enhanced neutrophil infiltration and expression of intercellular adhesion molecule-1 induced by renal ischemia/reperfusion. Treatment with nitroxyl anion releaser known as Angeli's salt abolished the beneficial effect of dexamethasone in renal ischemia/reperfusion. Renal dysfunction and tubular damage induced by renal ischemia/reperfusion were not ameliorated by pretreatment with dexamthasone. These results indicate that the attenuation by dexamethasone of neutrophil infiltration and intercellular adhesion molecule-1 expression during renal ischemia/reperfusion may be mediated by the suppressed production of nitroxyl anion. Thus, neutrophil infiltration in renal ischemia/reperfusion injury may be mediated, at least in part, by the enhanced production of nitroxyl anion.

Citing Articles

Comprehensive study of dexamethasone on albumin biogenesis during normal and pathological renal conditions.

Gong Q, Yin J, Wang M, He L, Lei F, Luo Y Pharm Biol. 2020; 58(1):1252-1262.

PMID: 33332210 PMC: 7751422. DOI: 10.1080/13880209.2020.1855214.


Epidemiologic and clinical characteristics of heart transplant recipients during the 2019 coronavirus outbreak in Wuhan, China: A descriptive survey report.

Ren Z, Hu R, Wang Z, Zhang M, Ruan Y, Wu Z J Heart Lung Transplant. 2020; 39(5):412-417.

PMID: 32362392 PMC: 7102567. DOI: 10.1016/j.healun.2020.03.008.


Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and sperm parameters following testicular torsion in a rat model.

Kazemi-Darabadi S, Asadpour R, Shahbazfar A, Alizadeh S Vet Res Forum. 2019; 10(2):125-132.

PMID: 31338145 PMC: 6626646. DOI: 10.30466/vrf.2019.74767.2002.


Corticosteroids and perinatal hypoxic-ischemic brain injury.

Concepcion K, Zhang L Drug Discov Today. 2018; 23(10):1718-1732.

PMID: 29778695 PMC: 6440944. DOI: 10.1016/j.drudis.2018.05.019.


Nicotine mediates hypochlorous acid-induced nuclear protein damage in mammalian cells.

Salama S, Arab H, Omar H, Maghrabi I, Snapka R Inflammation. 2013; 37(3):785-92.

PMID: 24357417 PMC: 4035441. DOI: 10.1007/s10753-013-9797-6.