Dexamethasone Attenuates Neutrophil Infiltration in the Rat Kidney in Ischemia/reperfusion Injury: the Possible Role of Nitroxyl
Overview
Biology
General Medicine
Authors
Affiliations
Neutrophil infiltration to the tissue, which is one of the important pathogenetic factors in ischemia/reperfusion injury, can be inhibited by glucocorticoids. The purpose of the present study was to clarify the mechanisms by which glucocorticoids inhibit neutrophil infiltration in renal ischemia/reperfusion injury in rats. Pretreatment with dexamethasone significantly attenuated the enhanced neutrophil infiltration and expression of intercellular adhesion molecule-1 induced by renal ischemia/reperfusion. Treatment with nitroxyl anion releaser known as Angeli's salt abolished the beneficial effect of dexamethasone in renal ischemia/reperfusion. Renal dysfunction and tubular damage induced by renal ischemia/reperfusion were not ameliorated by pretreatment with dexamthasone. These results indicate that the attenuation by dexamethasone of neutrophil infiltration and intercellular adhesion molecule-1 expression during renal ischemia/reperfusion may be mediated by the suppressed production of nitroxyl anion. Thus, neutrophil infiltration in renal ischemia/reperfusion injury may be mediated, at least in part, by the enhanced production of nitroxyl anion.
Gong Q, Yin J, Wang M, He L, Lei F, Luo Y Pharm Biol. 2020; 58(1):1252-1262.
PMID: 33332210 PMC: 7751422. DOI: 10.1080/13880209.2020.1855214.
Ren Z, Hu R, Wang Z, Zhang M, Ruan Y, Wu Z J Heart Lung Transplant. 2020; 39(5):412-417.
PMID: 32362392 PMC: 7102567. DOI: 10.1016/j.healun.2020.03.008.
Kazemi-Darabadi S, Asadpour R, Shahbazfar A, Alizadeh S Vet Res Forum. 2019; 10(2):125-132.
PMID: 31338145 PMC: 6626646. DOI: 10.30466/vrf.2019.74767.2002.
Corticosteroids and perinatal hypoxic-ischemic brain injury.
Concepcion K, Zhang L Drug Discov Today. 2018; 23(10):1718-1732.
PMID: 29778695 PMC: 6440944. DOI: 10.1016/j.drudis.2018.05.019.
Nicotine mediates hypochlorous acid-induced nuclear protein damage in mammalian cells.
Salama S, Arab H, Omar H, Maghrabi I, Snapka R Inflammation. 2013; 37(3):785-92.
PMID: 24357417 PMC: 4035441. DOI: 10.1007/s10753-013-9797-6.