Nicotine-induced Hypophagia and Hypodipsia in Deprived and in Hypothalamically Stimulated Rats

Overview

Journal Psychopharmacologia

Specialty Pharmacology

Date 1975 Jan 1

PMID 1153610

Citations 9

Authors

G Munster

K BATTIG

Affiliations

Soon will be listed here.

Abstract

Nicotine, in doses of 0.15 and 0.45 mg/kg, induced hypophagia and hypodipsia in 20 hrs-deprived rats and elevated the threshold currents for hypothalamically induced feeding and drinking in satiated rats. These effects were blocked by pretreatment with 0.5 mg/kg mecamylamine, but not by pretreatment with 3.0 or 9.0 mg/kg hexamethonium. These results indicate a centrally-located mechanism for the hypophagic and hypodipsic effect of single injections of nicotine.

Citing Articles

Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine's aversive effects in adolescent rats.

Harris A, Muelken P, Swain Y, Palumbo M, Jain V, Goniewicz M Drug Alcohol Depend. 2019; 203:51-60.

PMID: 31404849 PMC: 6941564. DOI: 10.1016/j.drugalcdep.2019.05.023.

Effect of nicotine on body composition in mice.

Mangubat M, Lutfy K, Lee M, Pulido L, Stout D, Davis R J Endocrinol. 2011; 212(3):317-26.

PMID: 22138237 PMC: 3444240. DOI: 10.1530/JOE-11-0350.

Attentional effects of nicotine and amphetamine in rats at different levels of motivation.

Bizarro L, Stolerman I Psychopharmacology (Berl). 2003; 170(3):271-277.

PMID: 12955304 DOI: 10.1007/s00213-003-1543-6.

Some effects of nicotine on food and water intake in undeprived rats.

CLARKE P, Kumar R Br J Pharmacol. 1984; 82(1):233-9.

PMID: 6539631 PMC: 1987251. DOI: 10.1111/j.1476-5381.1984.tb16463.x.

Effects of nicotine on body weight and food consumption in rats.

Grunberg N, Bowen D, Morse D Psychopharmacology (Berl). 1984; 83(1):93-8.

PMID: 6429707 DOI: 10.1007/BF00427430.

References

Brozek J, Keys A . Changes of body weight in normal men who stop smoking cigarettes. Science. 1957; 125(3259):1203. DOI: 10.1126/science.125.3259.1203. View

Grossman S . Eating or drinking elicited by direct adrenergic or cholinergic stimulation of hypothalamus. Science. 1960; 132(3422):301-2. DOI: 10.1126/science.132.3422.301. View

Stein L, SEIFTER J . Muscarinic synapses in the hypothalamus. Am J Physiol. 1962; 202:751-6. DOI: 10.1152/ajplegacy.1962.202.4.751. View

KERSHBAUM A, Bellet S, KHORSANDIAN R . ELEVATION OF SERUM CHOLESTEROL AFTER ADMINISTRATION OF NICOTINE. Am Heart J. 1965; 69:206-10. DOI: 10.1016/0002-8703(65)90038-4. View

Haggard H, Greenberg L . THE EFFECTS OF CIGARETTE SMOKING UPON THE BLOOD SUGAR. Science. 1934; 79(2042):165-6. DOI: 10.1126/science.79.2042.165. View

KOEHLER A, Hill E, Marsh N . The effect of cigarette smoking on malnutrition and digestion. Gastroenterology. 2010; 8(2):208-12. View

Myers R, Hall G, Rudy T . Drinking in the monkey evoked by nicotine or angiotensin II microinjected in hypothalamic and mesencephalic sites. Pharmacol Biochem Behav. 1973; 1(1):15-22. DOI: 10.1016/0091-3057(73)90049-x. View

Bhagat B . Influence of chronic administration of nicotine on the turnover and metabolism of noradrenaline in the rat brain. Psychopharmacologia. 1970; 18(4):325-32. DOI: 10.1007/BF00402759. View

Thompson J, George R . Chronic effects of nicotine on gastric secretion in rats with hypothalamic lesions. Am J Dig Dis. 1972; 17(6):513-8. DOI: 10.1007/BF02231206. View

10.

Wise R . Lateral hypothalamic electrical stimulation: does it make animals 'hungry'?. Brain Res. 1974; 67(2):187-209. DOI: 10.1016/0006-8993(74)90272-8. View

11.

ROSECRANS J . Brain area nicotine levels in male and female rats with different levels of spontaneous activity. Neuropharmacology. 1972; 11(6):863-70. DOI: 10.1016/0028-3908(72)90045-7. View

12.

Nelsen J, Goldstein L . Improvement of performance on an attention task with chronic nicotine treatment in rats. Psychopharmacologia. 1972; 26(4):347-60. DOI: 10.1007/BF00421900. View

13.

Hall G, Turner D . Effects of nicotine on the release of 3 H-noradrenaline from the hypothalamus. Biochem Pharmacol. 1972; 21(13):1829-38. DOI: 10.1016/0006-2952(72)90179-7. View

14.

Domino E, Lutz M . Tolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcement. Pharmacol Biochem Behav. 1973; 1(4):445-8. DOI: 10.1016/0091-3057(73)90011-7. View

15.

Baez L . Role of catecholamines in the anorectic effects of amphetamine in rats. Psychopharmacologia. 1974; 35(2):91-8. DOI: 10.1007/BF00429576. View

16.

Pradhan S, Bowling C . Effects of nicotine on self-stimulation in rats. J Pharmacol Exp Ther. 1971; 176(1):229-43. View

17.

KHOSLA T, Lowe C . Obesity and smoking habits. Br Med J. 1971; 4(5778):10-3. PMC: 1799170. DOI: 10.1136/bmj.4.5778.10. View

18.

Asghar K, ROTH L . Entry and distribution of hexamethonium in the central nervous system. Biochem Pharmacol. 1971; 20(10):2787-95. DOI: 10.1016/0006-2952(71)90189-4. View

19.

Carlson G, Ruddon R, HUG Jr C, Schmiege S, Bass P . Analysis of the site of nicotine action on gastric antral and duodenal contractile activity. J Pharmacol Exp Ther. 1970; 172(2):377-83. View

20.

Stark P, Turk J, Totty C . Reciprocal adrenergic and cholinergic control of hypothalamic elicited eating and satiety. Am J Physiol. 1971; 220(5):1516-21. DOI: 10.1152/ajplegacy.1971.220.5.1516. View