Nicotine and Smoking: a Perspective from Animal Studies

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1987 Jan 1

PMID 3110835

Citations 35

Authors

P B CLARKE

Affiliations

Soon will be listed here.

Abstract

Nicotine plays a key role in reinforcing tobacco smoking, and exerts several psychoneuropharmacological actions which may contribute to its reinforcing effects. Thus, nicotine can improve mood and alleviate withdrawal symptoms; it can also alter CNS arousal, reduce stress, suppress appetite, and improve performance on certain tasks. Behavioural studies in animals have tended to corroborate existing theories of smoking behaviour, and have started to suggest how and where nicotine may exert its central actions in man. Clinical evidence suggests that smoking cessation would be facilitated by the administration of a nicotinic antagonist having a selective action on central nicotinic cholinoceptors of the C6 (ganglionic) type. Pharmacological studies in animals indicate that such a drug is a reasonable prospect.

Citing Articles

Molecular composition of soil organic matter (SOM) regulate qualities of tobacco leaves.

Zhai X, Zhang L, Wu R, Wang M, Liu Y, Lian J Sci Rep. 2022; 12(1):15317.

PMID: 36097148 PMC: 9468172. DOI: 10.1038/s41598-022-19428-6.

Climatic factors determine the yield and quality of Honghe flue-cured tobacco.

Tang Z, Chen L, Chen Z, Fu Y, Sun X, Wang B Sci Rep. 2020; 10(1):19868.

PMID: 33199769 PMC: 7669845. DOI: 10.1038/s41598-020-76919-0.

Effects of enzymatic browning reaction on the usability of tobacco leaves and identification of components of reaction products.

Chen Y, Zhou J, Ren K, Zou C, Liu J, Yao G Sci Rep. 2019; 9(1):17850.

PMID: 31780730 PMC: 6882896. DOI: 10.1038/s41598-019-54360-2.

Enhancement of a visual reinforcer by D-amphetamine and nicotine in adult rats: relation to habituation and food restriction.

Wright J, Ren S, Constantin A, Clarke P Psychopharmacology (Berl). 2017; 235(3):803-814.

PMID: 29199358 DOI: 10.1007/s00213-017-4796-1.

Reinforcement enhancement by nicotine in adult rats: behavioral selectivity and relation to mode of delivery and blood nicotine levels.

Constantin A, Clarke P Psychopharmacology (Berl). 2017; 235(3):641-650.

PMID: 29128873 DOI: 10.1007/s00213-017-4778-3.

References

Cox B, Goldstein A, Nelson W . Nicotine self-administration in rats. Br J Pharmacol. 1984; 83(1):49-55. PMC: 1987179. DOI: 10.1111/j.1476-5381.1984.tb10118.x. View

Kumar R, Pratt J, Stolerman I . Characteristics of conditioned taste aversion produced by nicotine in rats. Br J Pharmacol. 1983; 79(1):245-53. PMC: 2044849. DOI: 10.1111/j.1476-5381.1983.tb10518.x. View

FLOOD J, Landry D, Jarvik M . Cholinergic receptor interactions and their effects on long-term memory processing. Brain Res. 1981; 215(1-2):177-85. DOI: 10.1016/0006-8993(81)90500-x. View

CLARKE P, Kumar R . The effects of nicotine on locomotor activity in non-tolerant and tolerant rats. Br J Pharmacol. 1983; 78(2):329-37. PMC: 2044704. DOI: 10.1111/j.1476-5381.1983.tb09398.x. View

Hughes J, Hatsukami D, Pickens R, Krahn D, Malin S, Luknic A . Effect of nicotine on the tobacco withdrawal syndrome. Psychopharmacology (Berl). 1984; 83(1):82-7. DOI: 10.1007/BF00427428. View

Hall G, Morrison C . New evidence for a relationship between tobacco smoking, nicotine dependence and stress. Nature. 1973; 243(5404):199-201. DOI: 10.1038/243199a0. View

Marks M, Collins A . Tolerance, cross-tolerance, and receptors after chronic nicotine or oxotremorine. Pharmacol Biochem Behav. 1985; 22(2):283-91. DOI: 10.1016/0091-3057(85)90392-2. View

Collins A, Evans C, Miner L, Marks M . Mecamylamine blockade of nicotine responses: evidence for two brain nicotinic receptors. Pharmacol Biochem Behav. 1986; 24(6):1767-73. DOI: 10.1016/0091-3057(86)90518-6. View

Ksir C, Hakan R, Hall Jr D, Kellar K . Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors. Neuropharmacology. 1985; 24(6):527-31. DOI: 10.1016/0028-3908(85)90058-9. View

10.

Goldberg S, Spealman R, Goldberg D . Persistent behavior at high rates maintained by intravenous self-administration of nicotine. Science. 1981; 214(4520):573-5. DOI: 10.1126/science.7291998. View

11.

Barrass B, Blackburn J, Brimblecombe R, Rich P . Modification of nicotine toxicity by pretreatment with different drugs. Biochem Pharmacol. 1969; 18(9):2145-52. DOI: 10.1016/0006-2952(69)90319-0. View

12.

Grunberg N, Bowen D, Morse D . Effects of nicotine on body weight and food consumption in rats. Psychopharmacology (Berl). 1984; 83(1):93-8. DOI: 10.1007/BF00427430. View

13.

CLARKE P, Hamill G, Nadi N, Jacobowitz D, Pert A . 3H-nicotine- and 125I-alpha-bungarotoxin-labeled nicotinic receptors in the interpeduncular nucleus of rats. II. Effects of habenular deafferentation. J Comp Neurol. 1986; 251(3):407-13. DOI: 10.1002/cne.902510311. View

14.

Domino E, Lutz M . Tolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcement. Pharmacol Biochem Behav. 1973; 1(4):445-8. DOI: 10.1016/0091-3057(73)90011-7. View

15.

Hendry J, ROSECRANS J . The development of pharmacological tolerance to the effect of nicotine on schedule-controlled responding in mice. Psychopharmacology (Berl). 1982; 77(4):339-43. DOI: 10.1007/BF00432767. View

16.

CLARKE P, Kumar R . Some effects of nicotine on food and water intake in undeprived rats. Br J Pharmacol. 1984; 82(1):233-9. PMC: 1987251. DOI: 10.1111/j.1476-5381.1984.tb16463.x. View

17.

Armitage A, Hall G, Morrison C . Pharmacological basis for the tobacco smoking habit. Nature. 1968; 217(5126):331-4. DOI: 10.1038/217331a0. View

18.

Grunberg N, Bowen D, Maycock V, Nespor S . The importance of sweet taste and caloric content in the effects of nicotine on specific food consumption. Psychopharmacology (Berl). 1985; 87(2):198-203. DOI: 10.1007/BF00431807. View

19.

CLARKE P, Pert A . Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons. Brain Res. 1985; 348(2):355-8. DOI: 10.1016/0006-8993(85)90456-1. View

20.

Morrison C, Stephenson J . Effects of stimulants on observed behaviour of rats on six operant schedules. Neuropharmacology. 1973; 12(4):297-310. DOI: 10.1016/0028-3908(73)90089-0. View