Cytokine Blockade in Rheumatoid Arthritis

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2001 Aug 17

PMID 11505970

Citations 18

Authors

M Feldmann

R N Maini

J Bondeson

P Taylor

B M Foxwell

F M Brennan

Affiliations

Soon will be listed here.

Abstract

As we enter the 2000's it is clear that cytokine blockade is an effective therapeutic strategy for rheumatoid arthritis. In this brief review, we will review the rationale for anti TNFalpha therapy, the current status of therapy and focus on the regulation of TNFalpha production in rheumatoid synovium. New approaches to studying TNF regulation in RA and of elucidating the controversial role of T cells in this complex disease will be described.

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