Role of Endogenous Interleukin-12 in Immune Response to Staphylococcal Enterotoxin B in Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2001 Aug 14

PMID 11500480

Citations 3

Authors

F N Lauw

S Florquin

P Speelman

S J van Deventer

T van der Poll

Affiliations

Soon will be listed here.

Abstract

In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.

Citing Articles

Staphylococcal enterotoxin B in vivo modulates both gamma interferon receptor expression and ligand-induced activation of signal transducer and activator of transcription 1 in T cells.

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Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus.

van der Sluijs K, van Elden L, Arens R, Nijhuis M, Schuurman R, Florquin S Immunology. 2004; 114(1):112-20.

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Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis.

Weijer S, Sewnath M, de Vos A, Florquin S, van der Sluis K, Gouma D Infect Immun. 2003; 71(10):5488-97.

PMID: 14500466 PMC: 201063. DOI: 10.1128/IAI.71.10.5488-5497.2003.

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