Design and Synthesis of a Highly Selective EP2-receptor Agonist

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2001 Jul 17

PMID 11454472

Citations 9

Authors

K Tani

A Naganawa

A Ishida

H Egashira

K Sagawa

H Harada

M Ogawa

T Maruyama

S Ohuchida

H Nakai

K Kondo

M Toda

Affiliations

Soon will be listed here.

Abstract

EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE(2) 2a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE(2) 2a stimulated uterine motility.

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