Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis

Overview

Journal Mol Biol Cell

Specialties Cell Biology
Molecular Biology

Date 2001 Jul 14

PMID 11452000

Citations 67

Authors

M T Hemann

K L Rudolph

M A Strong

R A DePinho

L Chin

C W Greider

Affiliations

Soon will be listed here.

Abstract

Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper meiotic chromosome segregation, it is unclear how mammalian telomere dysfunction results in germ cell death. To investigate the specific effects of telomere dysfunction on mammalian germ cell development, we examined the meiotic progression and germ cell apoptosis in late generation telomerase null mice. Our results indicate that chromosome asynapsis and missegregation are not the cause of infertility in mice with shortened telomeres. Rather, telomere dysfunction is recognized at the onset of meiosis, and cells with telomeric defects are removed from the germ cell precursor pool. This germ cell telomere surveillance may be an important mechanism to protect against the transmission of dysfunctional telomeres and chromosomal abnormalities.

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