Mucosal T Cell Response to Reovirus

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2001 Jul 11

PMID 11444387

Citations 5

Authors

D Chen

D H Rubin

Affiliations

Soon will be listed here.

Abstract

During the last three decades, immunologists and gastroenterologists have witnessed the formation of mucosal immunology as a discipline in biomedical science, and studies of reovirus infection have substantially contributed to this evolution. We have focused on mucosal T cell responses induced by reovirus in conventional, germfree, nude, and NF-kappaB deficient mice. Several major facets of T cell function in the immune responses to this mucosal pathogen have been examined, including viral selection of oligoclonal-T cells, extrathymic T cell development, and distinct signaling pathways used by CD8 sublineages. In addition, our findings with virus-specific T cells selected in the mucosa have suggested novel mechanisms for the rearrangement, selection, and expansion of TCR genes. With the increasing application of molecular tools, reovirus will continue to be a useful model pathogen to study mucosal immunology and will further our understanding of mucosal immunity in health and disease.

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References

Major A, Rubin D, Cuff C . Mucosal immunity to reovirus infection. Curr Top Microbiol Immunol. 1998; 233(Pt 2):163-77. DOI: 10.1007/978-3-642-72095-6_9. View

Chen D, Lee F, Cebra J, Rubin D . Predominant T-cell receptor Vbeta usage of intraepithelial lymphocytes during the immune response to enteric reovirus infection. J Virol. 1997; 71(5):3431-6. PMC: 191488. DOI: 10.1128/JVI.71.5.3431-3436.1997. View

Berek C, Berger A, Apel M . Maturation of the immune response in germinal centers. Cell. 1991; 67(6):1121-9. DOI: 10.1016/0092-8674(91)90289-b. View

Selb B, Weber B . A study of human reovirus IgG and IgA antibodies by ELISA and western blot. J Virol Methods. 1994; 47(1-2):15-25. DOI: 10.1016/0166-0934(94)90062-0. View

Letvin N, Kauffman R, Finberg R . T lymphocyte immunity to reovirus: cellular requirements for generation and role in clearance of primary infections. J Immunol. 1981; 127(6):2334-9. View

Scott J . A place in the world for RNA editing. Cell. 1995; 81(6):833-6. DOI: 10.1016/0092-8674(95)90002-0. View

von Boehmer H . Thymic selection: a matter of life and death. Immunol Today. 1992; 13(11):454-8. DOI: 10.1016/0167-5699(92)90075-I. View

Zheng B, Xue W, Kelsoe G . Locus-specific somatic hypermutation in germinal centre T cells. Nature. 1994; 372(6506):556-9. DOI: 10.1038/372556a0. View

Leclercq G, Plum J . Thymic and extrathymic T cell development. Leukemia. 1996; 10(12):1853-9. View

10.

Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo V, Weiner H . Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 1995; 376(6536):177-80. DOI: 10.1038/376177a0. View

11.

Sicinski P, Rowinski J, Warchol J, Jarzabek Z, GUT W, Szczygiel B . Poliovirus type 1 enters the human host through intestinal M cells. Gastroenterology. 1990; 98(1):56-8. DOI: 10.1016/0016-5085(90)91290-m. View

12.

Karapetian O, Shakhov A, Kraehenbuhl J, Acha-Orbea H . Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model. J Exp Med. 1994; 180(4):1511-6. PMC: 2191709. DOI: 10.1084/jem.180.4.1511. View

13.

Seko Y, Yagita H, Okumura K, Yazaki Y . T-cell receptor V beta gene expression in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3. Circulation. 1994; 89(5):2170-5. DOI: 10.1161/01.cir.89.5.2170. View

14.

Rubin D, Eaton M, Anderson A . Reovirus infection in adult mice: the virus hemagglutinin determines the site of intestinal disease. Microb Pathog. 1986; 1(1):79-87. PMC: 7172823. DOI: 10.1016/0882-4010(86)90034-3. View

15.

Horwitz M, Yanagi Y, Oldstone M . T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity. J Virol. 1994; 68(1):352-7. PMC: 236295. DOI: 10.1128/JVI.68.1.352-357.1994. View

16.

London S, Rubin D, Cebra J . Gut mucosal immunization with reovirus serotype 1/L stimulates virus-specific cytotoxic T cell precursors as well as IgA memory cells in Peyer's patches. J Exp Med. 1987; 165(3):830-47. PMC: 2188298. DOI: 10.1084/jem.165.3.830. View

17.

Rubin D, Weiner H, Fields B, Greene M . Immunologic tolerance after oral administration of reovirus: requirement for two viral gene products for tolerance induction. J Immunol. 1981; 127(4):1697-701. View

18.

Jamieson C, McCaffrey P, Rao A, Sen R . Physiologic activation of T cells via the T cell receptor induces NF-kappa B. J Immunol. 1991; 147(2):416-20. View

19.

Rocha B, von Boehmer H . Peripheral selection of the T cell repertoire. Science. 1991; 251(4998):1225-8. DOI: 10.1126/science.1900951. View

20.

Davis M, Bjorkman P . T-cell antigen receptor genes and T-cell recognition. Nature. 1988; 334(6181):395-402. DOI: 10.1038/334395a0. View