Depression: a Major, Unrecognized Risk Factor for Osteoporosis?

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2001 Jun 9

PMID 11397644

Citations 47

Authors

G Cizza

P Ravn

G P Chrousos

P W Gold

Affiliations

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Abstract

Existing studies of the relationship between depression and osteoporosis have been heterogeneous in their design and use of diagnostic instruments for depression, which might have contributed to the different results on the comorbidity of these two conditions. Nevertheless, these studies reveal a strong association between depression and osteoporosis. Endocrine factors such as depression-induced hypersecretion of corticotropin-releasing hormone and hypercortisolism, hypogonadism, growth hormone deficiency and increased concentration of circulating interleukin 6, might play a crucial role in the bone loss observed in subjects suffering from major depression.

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