Atmospheric Pressure Chemical Ionization Mass Spectrometry for Analysis of Lipids

Overview

Journal Lipids

Specialty Biochemistry

Date 2001 Jun 1

PMID 11383683

Citations 37

Authors

W C Byrdwell

Affiliations

Soon will be listed here.

Abstract

Atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) has proven to be a very valuable technique for analysis of lipids from a variety of classes. This instrumental method readily produces useful ions with gentle fragmentation from large neutral molecules such as triacylglycerols and carotenoids, which are often difficult to analyze using other techniques. Molecules that are easily ionized, such as phospholipids, produce molecular ions and diagnostically useful fragment ions that are complementary to those produced by methods such as electrospray ionization MS with collision-induced dissociation. The simplicity and versatility of APCI-MS make it an ideal tool for use in solving hitherto very difficult analytical problems.

Citing Articles

Text Mining and Computational Chemistry Reveal Trends in Applications of Laser Desorption/Ionization Techniques to Small Molecules.

Bergman N, Bergquist J, Hedeland M, Palmblad M J Am Soc Mass Spectrom. 2024; 35(10):2507-2515.

PMID: 39308355 PMC: 11457301. DOI: 10.1021/jasms.4c00293.

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism.

Danzi F, Pacchiana R, Mafficini A, Scupoli M, Scarpa A, Donadelli M Signal Transduct Target Ther. 2023; 8(1):137.

PMID: 36949046 PMC: 10033890. DOI: 10.1038/s41392-023-01380-0.

Gas Dynamic Virtual Nozzle Sprayer for an Introduction of Liquid Samples in Atmospheric Pressure Ionization Mass Spectrometry.

Kloudova B, Strmen T, Vrkoslav V, Chara Z, Paces O, Cvacka J Anal Chem. 2023; 95(8):4196-4203.

PMID: 36800482 PMC: 10016749. DOI: 10.1021/acs.analchem.2c05349.

Development of cVSSI-APCI for the Improvement of Ion Suppression and Matrix Effects in Complex Mixtures.

Pursell M, Sharif D, DeBastiani A, Li C, Majuta S, Li P Anal Chem. 2022; 94(26):9226-9233.

PMID: 35729103 PMC: 9260805. DOI: 10.1021/acs.analchem.1c05136.

The foundations and development of lipidomics.

Han X, Gross R J Lipid Res. 2021; 63(2):100164.

PMID: 34953866 PMC: 8953652. DOI: 10.1016/j.jlr.2021.100164.

References

Joos P, Van Ryckeghem M . Liquid chromatography-tandem mass spectrometry of some anabolic steroids. Anal Chem. 1999; 71(20):4701-10. DOI: 10.1021/ac981073s. View

Whitehouse C, Dreyer R, Yamashita M, Fenn J . Electrospray interface for liquid chromatographs and mass spectrometers. Anal Chem. 1985; 57(3):675-9. DOI: 10.1021/ac00280a023. View

HORNING E, Carroll D, Dzidic I, Haegele K, HORNING M, STILLWELL R . Atmospheric pressure ionization (API) mass spectrometry. Solvent-mediated ionization of samples introduced in solution and in a liquid chromatograph effluent stream. J Chromatogr Sci. 1974; 12(11):725-9. DOI: 10.1093/chromsci/12.11.725. View

Byrdwell W . Dual parallel mass spectrometers for analysis of sphingolipid, glycerophospholipid and plasmalogen molecular species. Rapid Commun Mass Spectrom. 1998; 12(5):256-72. DOI: 10.1002/(SICI)1097-0231(19980314)12:5<256::AID-RCM149>3.0.CO;2-8. View

Nakajima M, Yamato S, Shimada K . Determination of dehydroepiandrosterone sulphate in biological samples by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry using [7,7,16,16-2H4]-dehydroepiandrosterone sulphate as an internal standard. Biomed Chromatogr. 1998; 12(4):211-6. DOI: 10.1002/(SICI)1099-0801(199807/08)12:4<211::AID-BMC737>3.0.CO;2-N. View

Karlsson A, Michelsen P, Odham G . Molecular species of sphingomyelin: determination by high-performance liquid chromatography/mass spectrometry with electrospray and high-performance liquid chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization. J Mass Spectrom. 1999; 33(12):1192-8. DOI: 10.1002/(SICI)1096-9888(199812)33:12<1192::AID-JMS735>3.0.CO;2-J. View

Wang Y, Xu X, van Lieshout M, West C, Lugtenburg J, Verhoeven M . A liquid chromatography-mass spectrometry method for the quantification of bioavailability and bioconversion of beta-carotene to retinol in humans. Anal Chem. 2000; 72(20):4999-5003. DOI: 10.1021/ac000454e. View

Hagiwara T, Yasuno T, Funayama K, Suzuki S . Determination of lycopene, alpha-carotene and beta-carotene in serum by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry with selected-ion monitoring. J Chromatogr B Biomed Sci Appl. 1998; 708(1-2):67-73. DOI: 10.1016/s0378-4347(97)00669-5. View

Constanzer M, CHAVEZ C, Matuszewski B, Carlin J, Graham D . Low level determination of a novel 4-azasteroid and its carboxylic acid metabolite in human plasma and semen using high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 1997; 693(1):117-29. DOI: 10.1016/s0378-4347(97)00047-9. View

10.

Hopmans E, Schouten S, Pancost R, van der Meer M, Sinninghe Damste J . Analysis of intact tetraether lipids in archaeal cell material and sediments by high performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 2000; 14(7):585-9. DOI: 10.1002/(SICI)1097-0231(20000415)14:7<585::AID-RCM913>3.0.CO;2-N. View

11.

Shimada K . [Analysis of neurosteroids]. Yakugaku Zasshi. 1998; 117(10-11):681-9. DOI: 10.1248/yakushi1947.117.10-11_681. View

12.

van Breemen R, Nikolic D, Xu X, Xiong Y, van Lieshout M, West C . Development of a method for quantitation of retinol and retinyl palmitate in human serum using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. J Chromatogr A. 1998; 794(1-2):245-51. DOI: 10.1016/s0021-9673(97)01138-2. View

13.

Kusaka T, Ikeda M, Nakano H, NUMAJIRI Y . Liquid chromatography/mass spectrometry of fatty acids as their anilides. J Biochem. 1988; 104(4):495-7. DOI: 10.1093/oxfordjournals.jbchem.a122497. View

14.

Byrdwell W, Borchman D . Liquid chromatography/mass-spectrometric characterization of sphingomyelin and dihydrosphingomyelin of human lens membranes. Ophthalmic Res. 1997; 29(4):191-206. DOI: 10.1159/000268014. View

15.

Rule G, Henion J . High-throughput sample preparation and analysis using 96-well membrane solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of steroids in human urine. J Am Soc Mass Spectrom. 1999; 10(12):1322-7. DOI: 10.1016/S1044-0305(99)00107-5. View

16.

Shimada K, Mukai Y . Studies on neurosteroids. VII. Determination of pregnenolone and its 3-stearate in rat brains using high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J Chromatogr B Biomed Sci Appl. 1998; 714(2):153-60. View

17.

Lacker T, Strohschein S, Albert K . Separation and identification of various carotenoids by C30 reversed-phase high-performance liquid chromatography coupled to UV and atmospheric pressure chemical ionization mass spectrometric detection. J Chromatogr A. 1999; 854(1-2):37-44. DOI: 10.1016/s0021-9673(99)00584-1. View

18.

Ikeda M, Kusaka T . Liquid chromatography-mass spectrometry of hydroxy and non-hydroxy fatty acids as amide derivatives. J Chromatogr. 1992; 575(2):197-205. DOI: 10.1016/0378-4347(92)80146-h. View

19.

Tang G, Andrien B, Dolnikowski G, Russell R . Atmospheric pressure chemical ionization and electron capture negative chemical ionization mass spectrometry in studying beta-carotene conversion to retinol in humans. Methods Enzymol. 1997; 282:140-54. DOI: 10.1016/s0076-6879(97)82103-9. View

20.

Fredline V, Taylor P, Dodds H, Johnson A . A reference method for the analysis of aldosterone in blood by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Anal Biochem. 1997; 252(2):308-13. DOI: 10.1006/abio.1997.2340. View