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The Role of Superoxide Anion Radical in the Reduction of Ferritin Iron by Xanthine Oxidase

Overview
Journal J Clin Invest
Specialty General Medicine
Date 1974 Feb 1
PMID 11344583
Citations 4
Authors
D M Williams
G R Lee
G E CARTWRIGHT
Affiliations
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Abstract

Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the superoxide dismutase concentration was only about 1% of that found in normal porcine liver. These observations indicate that superoxide anion radical is an intermediate in the reduction of iron by xanthine oxidase in vitro but not in vivo.

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References
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