Spliceosomal UsnRNP Biogenesis, Structure and Function

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2001 May 10

PMID 11343899

Citations 290

Authors

C L Will

R Luhrmann

Affiliations

Soon will be listed here.

Abstract

Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6*U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.

Citing Articles

Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5.

Jin C, Hunkeler M, Mulvaney K, Sellers W, Fischer E J Biol Chem. 2025; 301(2):108165.

PMID: 39793893 PMC: 11847536. DOI: 10.1016/j.jbc.2025.108165.

Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets.

Jeon S, Jeon Y, Lim J, Kim Y, Cha B, Kim W Signal Transduct Target Ther. 2025; 10(1):4.

PMID: 39757214 PMC: 11701242. DOI: 10.1038/s41392-024-02070-1.

The 'genetic zipper' method offers a cost-effective solution for aphid control.

Oberemok V, Puzanova Y, Galchinsky N Front Insect Sci. 2024; 4:1467221.

PMID: 39726916 PMC: 11670321. DOI: 10.3389/finsc.2024.1467221.

Alternative splicing in ovarian cancer.

Wei L, Li Y, Chen J, Wang Y, Wu J, Yang H Cell Commun Signal. 2024; 22(1):507.

PMID: 39425166 PMC: 11488268. DOI: 10.1186/s12964-024-01880-8.

Defenders of the Transcriptome: Guard Protein-Mediated mRNA Quality Control in .

Querl L, Krebber H Int J Mol Sci. 2024; 25(19).

PMID: 39408571 PMC: 11476243. DOI: 10.3390/ijms251910241.