Growth Factor Treatment Enhances Vestibular Hair Cell Renewal and Results in Improved Vestibular Function

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2001 May 2

PMID 11331776

Citations 19

Authors

R D Kopke

R L Jackson

G Li

M D Rasmussen

M E Hoffer

D A Frenz

M Costello

P Schultheiss

T R Van De Water

Affiliations

Soon will be listed here.

Abstract

The vestibules of adult guinea pigs were lesioned with gentamicin and then treated with perilymphatic infusion of either of two growth factor mixtures (i.e., GF I or GF II). GF I contained transforming growth factor alpha (TGFalpha), insulin-like growth factor type one (IGF-1), and retinoic acid (RA), whereas GF II contained those three factors and brain-derived neurotrophic factor. Treatment with GF I significantly enhanced vestibular hair cell renewal in ototoxin-damaged utricles and the maturation of stereociliary bundle morphology. The addition of brain-derived neurotrophic factor to the GF II infusion mixture resulted in the return of type 1 vestibular hair cells in ototoxin-damaged cristae, and improved vestibular function. These results suggest that growth factor therapy may be an effective treatment for balance disorders that are the result of hair cell dysfunction and/or loss.

Citing Articles

Oral Administration of TrkB Agonist, 7, 8-Dihydroxyflavone Regenerates Hair Cells and Restores Function after Gentamicin-Induced Vestibular Injury in Guinea Pig.

Kinoshita M, Fujimoto C, Iwasaki S, Kondo K, Yamasoba T Pharmaceutics. 2023; 15(2).

PMID: 36839815 PMC: 9966733. DOI: 10.3390/pharmaceutics15020493.

Regeneration of Hair Cells in the Human Vestibular System.

Huang Y, Mao H, Chen Y Front Mol Neurosci. 2022; 15:854635.

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Progress in protecting vestibular hair cells.

Jiang L, Zheng Z, He Y Arch Toxicol. 2021; 95(8):2613-2623.

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Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs.

Du X, Cai Q, West M, Youm I, Huang X, Li W Mol Ther. 2018; 26(5):1313-1326.

PMID: 29680697 PMC: 5993961. DOI: 10.1016/j.ymthe.2018.03.004.

Regeneration of hair cells in the mammalian vestibular system.

Li W, You D, Chen Y, Chai R, Li H Front Med. 2016; 10(2):143-51.

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