Dimeric L-dopa Derivatives As Potential Prodrugs

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2001 May 1

PMID 11327596

Citations 6

Authors

A Di Stefano

B Mosciatti

G M Cingolani

G Giorgioni

M Ricciutelli

I Cacciatore

P Sozio

F Claudi

Affiliations

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Abstract

A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.

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