Hypothesis: is a Failure to Prevent Bacteriolysis and the Synergy Among Microbial and Host-derived Pro-inflammatory Agonists the Main Contributory Factors to the Pathogenesis of Post-infectious Sequelae?

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2001 Apr 11

PMID 11293661

Citations 1

Authors

I Ginsburg

Affiliations

Soon will be listed here.

Citing Articles

Cationic polyelectrolytes from leukocytes might kill bacteria by activating their autolytic systems: enigmatically, the relevance of this phenomenon to post-infectious sequelae is disregarded.

Ginsburg I Intensive Care Med. 2002; 28(8):1188.

PMID: 12400517 DOI: 10.1007/s00134-002-1385-4.

References

Sevransky J, Shaked G, Novogrodsky A, Levitzki A, Gazit A, Hoffman A . Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis. J Clin Invest. 1997; 99(8):1966-73. PMC: 508021. DOI: 10.1172/JCI119364. View

Weiss M, Moldawer L, Schneider E . Granulocyte colony-stimulating factor to prevent the progression of systemic nonresponsiveness in systemic inflammatory response syndrome and sepsis. Blood. 1999; 93(2):425-39. View

Sieradzki K, Tomasz A . Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus. J Bacteriol. 1997; 179(8):2557-66. PMC: 179004. DOI: 10.1128/jb.179.8.2557-2566.1997. View

Parsons P . Interleukin-10: the ambiguity in sepsis continues. Crit Care Med. 1998; 26(5):818-9. DOI: 10.1097/00003246-199805000-00007. View

Wheeler A, Bernard G . Treating patients with severe sepsis. N Engl J Med. 1999; 340(3):207-14. DOI: 10.1056/NEJM199901213400307. View

Ginsburg I . Mechanisms of cell and tissue injury induced by group A streptococci: relation to poststreptococcal sequelae. J Infect Dis. 1972; 126(3):294-340. DOI: 10.1093/infdis/126.3.294. View

Opal S, Yu Jr R . Antiendotoxin strategies for the prevention and treatment of septic shock. New approaches and future directions. Drugs. 1998; 55(4):497-508. DOI: 10.2165/00003495-199855040-00002. View

Holzheimer R . The significance of endotoxin release in experimental and clinical sepsis in surgical patients--evidence for antibiotic-induced endotoxin release?. Infection. 1998; 26(2):77-84. DOI: 10.1007/BF02767765. View

Vincent J . Clinical trials in sepsis: where do we stand?. J Crit Care. 1997; 12(1):3-6. DOI: 10.1016/s0883-9441(97)90019-8. View

10.

Ginsburg I, Kohen R . Cell damage in inflammatory and infectious sites might involve a coordinated "cross-talk" among oxidants, microbial haemolysins and ampiphiles, cationic proteins, phospholipases, fatty acids, proteinases and cytokines (an overview). Free Radic Res. 1995; 22(6):489-517. DOI: 10.3109/10715769509150323. View

11.

Steinhauser M, Hogaboam C, Lukacs N, Strieter R, Kunkel S . Multiple roles for IL-12 in a model of acute septic peritonitis. J Immunol. 1999; 162(9):5437-43. View

12.

Lukomski S, Sreevatsan S, AMBERG C, Reichardt W, Woischnik M, Podbielski A . Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains. J Clin Invest. 1997; 99(11):2574-80. PMC: 508102. DOI: 10.1172/JCI119445. View

13.

Elsbach P . The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense. J Leukoc Biol. 1998; 64(1):14-8. DOI: 10.1002/jlb.64.1.14. View

14.

Zeni F, Freeman B, Natanson C . Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med. 1997; 25(7):1095-100. DOI: 10.1097/00003246-199707000-00001. View

15.

Ginsburg I, Sadovnik M, Sallon S, Milo-Goldzweig I, Mechoulam R, Breuer A . PADMA-28, a traditional tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids. Inflammopharmacology. 2007; 7(1):47-62. DOI: 10.1007/s10787-999-0025-9. View

16.

Faist E, Kim C . Therapeutic immunomodulatory approaches for the control of systemic inflammatory response syndrome and the prevention of sepsis. New Horiz. 1998; 6(2 Suppl):S97-102. View

17.

Rodell T, Cheronis J, Repine J . Endothelial cell xanthine oxidase-derived toxic oxygen metabolites contribute to acute lung injury from neutrophil elastase. Chest. 1988; 93(3 Suppl):146S. DOI: 10.1378/chest.93.3_supplement.146s. View

18.

Baggiolini M, Moser B . Blocking chemokine receptors. J Exp Med. 1998; 186(8):1189-91. PMC: 2199102. DOI: 10.1084/jem.186.8.1189. View

19.

Lehmann C, Egerer K, Georgiew A, Weber M, Grune T, Kox W . Inhibition of tumor necrosis factor-alpha release in rat experimental endotoxemia by treatment with the 21-aminosteroid U-74389G. Crit Care Med. 1999; 27(6):1164-7. DOI: 10.1097/00003246-199906000-00044. View

20.

Stevens D . Rationale for the use of intravenous gamma globulin in the treatment of streptococcal toxic shock syndrome. Clin Infect Dis. 1998; 26(3):639-41. DOI: 10.1086/514585. View