Caspases: More Than Just Killers?

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2001 Apr 5

PMID 11286689

Citations 43

Authors

M Los

C Stroh

R U Janicke

I H Engels

K Schulze-Osthoff

Affiliations

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Abstract

Proteases of the caspase family constitute the central executioners of apoptosis. Several recent observations suggest that caspases and apoptosis-regulatory molecules exert important functions beyond that of cell death, including the control of T-cell proliferation and cell-cycle progression. Here, Los and colleagues propose a model that directly connects cell suicide mechanisms to the regulation of cell-cycle progression.

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