Cbl: Many Adaptations to Regulate Protein Tyrosine Kinases

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2001 Apr 3

PMID 11283727

Citations 222

Authors

C B Thien

W Y Langdon

Affiliations

Soon will be listed here.

Abstract

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

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