The Roles of Ubiquitination in AML

Overview

Journal Ann Hematol

Specialty Hematology

Date 2023 Aug 21

PMID 37603061

Authors

Zhifeng Wei

Long Su

Sujun Gao

Affiliations

Soon will be listed here.

Abstract

Acute myeloid leukemia (AML) is a heterogeneously malignant disorder resulting in poor prognosis. Ubiquitination, a major post-translational modification (PTM), plays an essential role in regulating various cellular processes and determining cell fate. Despite these initial insights, the precise role of ubiquitination in AML pathogenesis and treatment remains largely unknown. In order to address this knowledge gap, we explore the relationship between ubiquitination and AML from the perspectives of signal transduction, cell differentiation, and cell cycle control; and try to find out how this relationship can be utilized to inform new therapeutic strategies for AML patients.

Citing Articles

Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML.

Zhang Z, Lin X, Yang Y, Wang X, Wang Y, Huang X Cancer Biol Ther. 2025; 26(1):2459426.

PMID: 39878157 PMC: 11781246. DOI: 10.1080/15384047.2025.2459426.

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