HNF1alpha Controls Renal Glucose Reabsorption in Mouse and Man

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2001 Mar 28

PMID 11269503

Citations 61

Authors

M Pontoglio

D Prie

C Cheret

A Doyen

C Leroy

P Froguel

G Velho

M Yaniv

G Friedlander

Affiliations

Soon will be listed here.

Abstract

Recently it has been shown that dominant mutations in the human hepatocyte nuclear factor 1alpha (HNF1alpha) gene, encoding for a homeoprotein that is expressed in liver, kidney, pancreas and intestine, result in maturity onset diabetes of the young type 3 (MODY3). HNF1alpha-null mice are diabetic, but at the same time suffer from a renal Fanconi syndrome characterized by urinary glucose loss. Here we show that MODY3 patients are also characterized by a reduced tubular reabsorption of glucose. The renal murine defect is due to reduced expression of the low affinity/high capacity glucose cotransporter (SGLT2). Our results show that HNF1alpha directly controls SGLT2 gene expression. Together these data indicate that HNF1alpha plays a key role in glucose homeostasis in mammals.

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