In Vivo Pharmacokinetics and Pharmacodynamics in Drug Development Using Positron-emission Tomography

Overview

Journal Drug Discov Today

Specialty Pharmacology

Date 2001 Mar 21

PMID 11257581

Citations 25

Authors

E O Aboagye

P M Price

T Jones

Affiliations

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Abstract

Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics non-invasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: elucidation of pathophysiology, evaluation of pharmacokinetics, proof of principle of mechanism, and assessment of efficacy and/or response to therapy.

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