Diffusion-weighted Imaging of the Spine Using Radial K-space Trajectories

Overview

Journal MAGMA

Publisher Springer

Date 2001 Mar 20

PMID 11255089

Citations 9

Authors

O Dietrich

A Herlihy

W R Dannels

J Fiebach

S Heiland

J V Hajnal

K Sartor

Affiliations

Soon will be listed here.

Abstract

Introduction: Diffusion-weighted MR imaging (DWI) of the spine requires robust imaging methods, that are insensitive to susceptibility effects caused by the transition from bone to soft tissue and motion artifacts due to breathing, swallowing, and cardiac motion. The purpose of this study was to develop a robust imaging method suitable for DWI of the spine.

Methods And Subjects: A radial k-space spin echo sequence has been implemented, which is self-navigating because each acquisition line passes through the origin of k-space. Influence of cardiac motion and associated flow of cerebrospinal fluid is minimized by cardiac gating with a finger photoplethysmograph. The sequence has been tested on a 1.5T system. Diffusion-weighted images of six normal volunteers were acquired in the sagittal plane with 4 b values between 50 and 500 s mm(-2). Because of the symmetries of the cord, diffusion measurements in the head-foot (HF) or left-right (LR) directions were sufficient to measure the dominant effects of anisotropy.

Results: The apparent diffusion coefficients (ADCs) measured, respectively, in the LR and HF directions were (0.699+/-0.050)x10(-3) and (1.805+/-0.086)x10(-3) mm(2) s(-1) in the spinal cord, (1.588+/-0.082)x10(-3) and (1.528+/-0.052)x10(-3) mm(2) s(-1) in the intervertebral disks, and (0.346+/-0.047)x10(-3) and (0.306+/-0.035)x10(-3) mm(2) s(-1) in the vertebrae of the cervicothoracic spine.

Conclusion: Diffusion-weighted spin echo sequences with radial trajectories in k-space provide a means of achieving robust, high quality diffusion-weighted imaging and measuring ADCs in the spine. The application of the diffusion-weighting gradients in different directions allows diffusion anisotropy to be measured.

Citing Articles

Post-contrast T1-weighted spine 3T MRI in children using a golden-angle radial acquisition.

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Multiparameter MRI assessment of normal-appearing and diseased vertebral bone marrow.

Biffar A, Baur-Melnyk A, Schmidt G, Reiser M, Dietrich O Eur Radiol. 2010; 20(11):2679-89.

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3D diffusion tensor MRI with isotropic resolution using a steady-state radial acquisition.

Jung Y, Samsonov A, Block W, Lazar M, Lu A, Liu J J Magn Reson Imaging. 2009; 29(5):1175-84.

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Feasibility of a RARE-based sequence for quantitative diffusion-weighted MRI of the spine.

Raya J, Dietrich O, Birkenmaier C, Sommer J, Reiser M, Baur-Melnyk A Eur Radiol. 2007; 17(11):2872-9.

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A preliminary study of the effects of trigger timing on diffusion tensor imaging of the human spinal cord.

Summers P, Staempfli P, Jaermann T, Kwiecinski S, Kollias S AJNR Am J Neuroradiol. 2006; 27(9):1952-61.

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References

Pierpaoli C, Jezzard P, Basser P, Barnett A, DI CHIRO G . Diffusion tensor MR imaging of the human brain. Radiology. 1996; 201(3):637-48. DOI: 10.1148/radiology.201.3.8939209. View

Xing D, Papadakis N, Huang C, Lee V, Carpenter T, Hall L . Optimised diffusion-weighting for measurement of apparent diffusion coefficient (ADC) in human brain. Magn Reson Imaging. 1997; 15(7):771-84. DOI: 10.1016/s0730-725x(97)00037-4. View

Jones D, Lythgoe D, Horsfield M, Simmons A, Williams S, Markus H . Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI. Stroke. 1999; 30(2):393-7. DOI: 10.1161/01.str.30.2.393. View

Werring D, Clark C, Barker G, Thompson A, Miller D . Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology. 1999; 52(8):1626-32. DOI: 10.1212/wnl.52.8.1626. View

Moseley M, Cohen Y, Mintorovitch J, Chileuitt L, Shimizu H, Kucharczyk J . Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Reson Med. 1990; 14(2):330-46. DOI: 10.1002/mrm.1910140218. View

Clark C, Barker G, Tofts P . Magnetic resonance diffusion imaging of the human cervical spinal cord in vivo. Magn Reson Med. 1999; 41(6):1269-73. DOI: 10.1002/(sici)1522-2594(199906)41:6<1269::aid-mrm26>3.0.co;2-2. View

Sugahara T, Korogi Y, Kochi M, Ikushima I, SHIGEMATU Y, Hirai T . Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging. 1999; 9(1):53-60. DOI: 10.1002/(sici)1522-2586(199901)9:1<53::aid-jmri7>3.0.co;2-2. View

Schomberg H, Timmer J . The gridding method for image reconstruction by Fourier transformation. IEEE Trans Med Imaging. 1995; 14(3):596-607. DOI: 10.1109/42.414625. View

Weber J, Mattle H, Heid O, Remonda L, Schroth G . Diffusion-weighted imaging in ischaemic stroke: a follow-up study. Neuroradiology. 2000; 42(3):184-91. DOI: 10.1007/s002340050042. View

10.

Trouard T, Sabharwal Y, Altbach M, Gmitro A . Analysis and comparison of motion-correction techniques in diffusion-weighted imaging. J Magn Reson Imaging. 1996; 6(6):925-35. DOI: 10.1002/jmri.1880060614. View

11.

Kerttula L, Jauhiainen J, Tervonen O, Suramo I, Koivula A, Oikarinen J . Apparent diffusion coefficient in thoracolumbar intervertebral discs of healthy young volunteers. J Magn Reson Imaging. 2000; 12(2):255-60. DOI: 10.1002/1522-2586(200008)12:2<255::aid-jmri7>3.0.co;2-t. View

12.

Tievsky A, Ptak T, Farkas J . Investigation of apparent diffusion coefficient and diffusion tensor anisotrophy in acute and chronic multiple sclerosis lesions. AJNR Am J Neuroradiol. 1999; 20(8):1491-9. PMC: 7657750. View

13.

Finsterbusch J, Frahm J . Diffusion-weighted single-shot line scan imaging of the human brain. Magn Reson Med. 1999; 42(4):772-8. DOI: 10.1002/(sici)1522-2594(199910)42:4<772::aid-mrm20>3.0.co;2-8. View

14.

Cercignani M, Iannucci G, Rocca M, Comi G, Horsfield M, Filippi M . Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI. Neurology. 2000; 54(5):1139-44. DOI: 10.1212/wnl.54.5.1139. View

15.

Li T, Takahashi A, Hindmarsh T, Moseley M . ADC mapping by means of a single-shot spiral MRI technique with application in acute cerebral ischemia. Magn Reson Med. 1999; 41(1):143-7. DOI: 10.1002/(sici)1522-2594(199901)41:1<143::aid-mrm20>3.0.co;2-o. View

16.

Trouard T, Theilmann R, Altbach M, Gmitro A . High-resolution diffusion imaging with DIFRAD-FSE (diffusion-weighted radial acquisition of data with fast spin-echo) MRI. Magn Reson Med. 1999; 42(1):11-8. DOI: 10.1002/(sici)1522-2594(199907)42:1<11::aid-mrm3>3.0.co;2-j. View

17.

Gmitro A, Alexander A . Use of a projection reconstruction method to decrease motion sensitivity in diffusion-weighted MRI. Magn Reson Med. 1993; 29(6):835-8. DOI: 10.1002/mrm.1910290619. View

18.

Pipe J . Motion correction with PROPELLER MRI: application to head motion and free-breathing cardiac imaging. Magn Reson Med. 1999; 42(5):963-9. DOI: 10.1002/(sici)1522-2594(199911)42:5<963::aid-mrm17>3.0.co;2-l. View

19.

Kim Y, Chang K, Song I, Kim H, Seong S, Kim Y . Brain abscess and necrotic or cystic brain tumor: discrimination with signal intensity on diffusion-weighted MR imaging. AJR Am J Roentgenol. 1998; 171(6):1487-90. DOI: 10.2214/ajr.171.6.9843275. View

20.

Seifert M, Jakob P, Jellus V, Haase A, Hillenbrand C . High-resolution diffusion imaging using a radial turbo-spin-echo sequence: implementation, eddy current compensation, and self-navigation. J Magn Reson. 2000; 144(2):243-54. DOI: 10.1006/jmre.2000.2041. View