Antioxidants in Health and Disease

Overview

Journal J Clin Pathol

Specialty Pathology

Date 2001 Mar 17

PMID 11253127

Citations 366

Authors

I S Young

J V Woodside

Affiliations

Soon will be listed here.

Abstract

Free radical production occurs continuously in all cells as part of normal cellular function. However, excess free radical production originating from endogenous or exogenous sources might play a role in many diseases. Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition. This article reviews the basic chemistry of free radical formation in the body, the consequences of free radical induced tissue damage, and the function of antioxidant defence systems, with particular reference to the development of atherosclerosis.

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