Human Cancer Cell Lines: Fact and Fantasy

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2001 Mar 17

PMID 11252900

Citations 117

Authors

J R Masters

Affiliations

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Abstract

Cancer cell lines are used in many biomedical research laboratories. Why, then, are they often described as unrepresentative of the cells from which they were derived? Here, I argue that they have been unjustly accused. Under the right conditions, and with appropriate controls, properly authenticated cancer cell lines retain the properties of the cancers of origin.

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