Cannabinoid Receptor Antagonist SR141716A Decreases Operant Ethanol Self Administration in Rats Exposed to Ethanol-vapor Chambers

Overview

Journal Zhongguo Yao Li Xue Bao

Publisher Science Press

Specialty Pharmacology

Date 2001 Feb 24

PMID 11189201

Citations 33

Authors

F Rodriguez de Fonseca

A J Roberts

A Bilbao

G F Koob

M Navarro

Affiliations

Soon will be listed here.

Abstract

Aim: To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration.

Methods: We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers.

Results: Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A.

Conclusion: These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism.

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