In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria Gonorrhoeae

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1979 Mar 1

PMID 111612

Citations 14

Authors

P R Murray

J L Christman

G Medoff

Affiliations

Soon will be listed here.

Abstract

The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseria gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of >/=0.5 mug/ml for penicillin) and three beta-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 mug/ml and all inhibited by 0.25 mug/ml.

Citing Articles

Competition of beta-lactam antibiotics for the penicillin-binding proteins of Neisseria gonorrhoeae.

Dougherty T, Koller A, Tomasz A Antimicrob Agents Chemother. 1981; 20(1):109-14.

PMID: 6792979 PMC: 181641. DOI: 10.1128/AAC.20.1.109.

Neisseria gonorrhoeae strains isolated in Hong Kong: in vitro susceptibility to 13 antibiotics.

Ng W, Anton P, Arnold K Antimicrob Agents Chemother. 1981; 19(1):12-7.

PMID: 6787976 PMC: 181349. DOI: 10.1128/AAC.19.1.12.

The third generation cephalosporins.

Farber B, Moellering Jr R Bull N Y Acad Med. 1982; 58(8):696-710.

PMID: 6762896 PMC: 1805373.

In vitro susceptibility of 50 non-beta-lactamase-producing Neisseria gonorrhoeae strains to 12 antimicrobial agents.

Rodriguez J, KOURI Y, Cuevas R, Nevarez M, Perez M Antimicrob Agents Chemother. 1983; 23(2):242-4.

PMID: 6404217 PMC: 186029. DOI: 10.1128/AAC.23.2.242.

Comparative efficacy of cefmenoxime versus penicillin in the treatment of gonorrhea.

Obaid S, Khan M, Simpson M, Gruninger R, Wigren D Antimicrob Agents Chemother. 1983; 23(3):349-51.

PMID: 6303209 PMC: 184649. DOI: 10.1128/AAC.23.3.349.

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