Sun Y, Jenkins L, El Touny L, Zhu L, Yang X, Jo U
Sci Adv. 2025; 11(2):eads2919.
PMID: 39792662
PMC: 11721697.
DOI: 10.1126/sciadv.ads2919.
Weickert P, Durauer S, Gotz M, Li H, Stingele J
Nat Protoc. 2024; 19(10):2891-2914.
PMID: 38890499
DOI: 10.1038/s41596-024-01004-z.
Torrecilla I, Ruggiano A, Kiianitsa K, Aljarbou F, Lascaux P, Hoslett G
Nucleic Acids Res. 2023; 52(2):525-547.
PMID: 38084926
PMC: 10810220.
DOI: 10.1093/nar/gkad1178.
Perry M, Ghosal G
Methods Mol Biol. 2023; 2701:135-148.
PMID: 37574479
DOI: 10.1007/978-1-0716-3373-1_8.
Tan Y, Yao L, Gamliel A, Nair S, Taylor H, Ohgi K
Nat Struct Mol Biol. 2023; 30(2):148-158.
PMID: 36747093
PMC: 9935399.
DOI: 10.1038/s41594-022-00883-8.
SPRTN patient variants cause global-genome DNA-protein crosslink repair defects.
Weickert P, Li H, Gotz M, Durauer S, Yaneva D, Zhao S
Nat Commun. 2023; 14(1):352.
PMID: 36681662
PMC: 9867749.
DOI: 10.1038/s41467-023-35988-1.
Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair.
Aditi , Downing S, Schreiner P, Kwak Y, Li Y, Shaw T
Neuron. 2021; 109(24):3962-3979.e6.
PMID: 34655526
PMC: 8686690.
DOI: 10.1016/j.neuron.2021.09.040.
Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast.
Stantial N, Rogojina A, Gilbertson M, Sun Y, Miles H, Shaltz S
Proc Natl Acad Sci U S A. 2020; 117(43):26876-26884.
PMID: 33046655
PMC: 7604471.
DOI: 10.1073/pnas.2008721117.
The Aza-Analogous Benzo[]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties.
Aichinger G, Lichtenberger F, Steinhauer T, Florkemeier I, Del Favero G, Clement B
Molecules. 2020; 25(7).
PMID: 32230817
PMC: 7180443.
DOI: 10.3390/molecules25071524.
The "adductome": A limited repertoire of adducted proteins in human cells.
Kiianitsa K, Maizels N
DNA Repair (Amst). 2020; 89:102825.
PMID: 32109764
PMC: 7197468.
DOI: 10.1016/j.dnarep.2020.102825.
Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4β-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin.
Sun L, Zhu L, Tang Y
Sci Rep. 2018; 8(1):14949.
PMID: 30297860
PMC: 6175940.
DOI: 10.1038/s41598-018-33366-2.
Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' Adducts.
Yan H, Tammaro M, Liao S
Genes (Basel). 2016; 7(7).
PMID: 27376333
PMC: 4962002.
DOI: 10.3390/genes7070032.
Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.
Perkins A, Peterson K, Beito T, Flatten K, Kaufmann S, Harki D
Org Biomol Chem. 2016; 14(17):4103-9.
PMID: 27113574
PMC: 4922793.
DOI: 10.1039/c5ob02049b.
Immunodetection of human topoisomerase I-DNA covalent complexes.
Patel A, Flatten K, Peterson K, Beito T, Schneider P, Perkins A
Nucleic Acids Res. 2016; 44(6):2816-26.
PMID: 26917015
PMC: 4824114.
DOI: 10.1093/nar/gkw109.
Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.
Hasinoff B, Wu X, Patel D, Kanagasabai R, Karmahapatra S, Yalowich J
J Pharmacol Exp Ther. 2015; 356(2):397-409.
PMID: 26660439
PMC: 4746493.
DOI: 10.1124/jpet.115.228650.
Resveratrol modulates the topoisomerase inhibitory potential of doxorubicin in human colon carcinoma cells.
Schroeter A, Marko D
Molecules. 2014; 19(12):20054-72.
PMID: 25470274
PMC: 6271354.
DOI: 10.3390/molecules191220054.
Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.
Yadav A, Wu X, Patel D, Yalowich J, Hasinoff B
Bioorg Med Chem. 2014; 22(21):5935-49.
PMID: 25282653
PMC: 4254203.
DOI: 10.1016/j.bmc.2014.09.014.
Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation.
Marinello J, Chillemi G, Bueno S, Manzo S, Capranico G
Nucleic Acids Res. 2013; 41(22):10110-23.
PMID: 23999093
PMC: 3905886.
DOI: 10.1093/nar/gkt778.
Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1.
Fehr M, Baechler S, Kropat C, Mielke C, Boege F, Pahlke G
Mycotoxin Res. 2013; 26(4):247-56.
PMID: 23605487
DOI: 10.1007/s12550-010-0063-6.
A rapid and sensitive assay for DNA-protein covalent complexes in living cells.
Kiianitsa K, Maizels N
Nucleic Acids Res. 2013; 41(9):e104.
PMID: 23519618
PMC: 3643584.
DOI: 10.1093/nar/gkt171.
