Pituitary Lymphoma: a Case Report and Literature Review

Overview

Journal Pituitary

Specialty Endocrinology

Date 2000 Nov 18

PMID 11081150

Citations 20

Authors

R A Mathiasen

R Jarrahy

S T Cha

K Kovacs

V S Herman

E Ginsberg

H K Shahinian

Affiliations

Soon will be listed here.

Abstract

We report the case of a B-cell type pituitary lymphoma in a 65 year-old male immunocompetent patient who presented with hypogonadotropic hypogonadism and central hypothyroidism and subsequently developed pulmonary lymphoma. Only three cases of pituitary lymphoma have been previously reported, one in a patient with acquired immunodeficiency syndrome, one case of T-cell lymphoma reported in the Japanese literature, and one case of B-cell lymphoma. The previously reported immunocompetent patients presented with signs and symptoms of optic chiasm compression as contrasted to our patient's endocrinologic presentation. B-cell lymphoma of the pituitary gland is a exceedingly rare though distinct clinical entity.

Citing Articles

A Biphasic Presentation of Diffuse Large B-cell Lymphoma Metastasis to the Hypothalamus-pituitary Axis: A Case Report and Literature Review.

Alghzawi F, Martinez-Cruz M, Bhat S, Haas C J Community Hosp Intern Med Perspect. 2024; 14(5):128-134.

PMID: 39399182 PMC: 11466330. DOI: 10.55729/2000-9666.1393.

Pituitary Infiltration by Lymphoma.

Tovar-Mendez V, Cuenca D, Gomez-Perez F, Cuevas-Ramos D J Endocr Soc. 2022; 6(12):bvac161.

PMID: 36397777 PMC: 9664974. DOI: 10.1210/jendso/bvac161.

Intravascular large B-cell lymphoma presenting with reticular telangiectasia on the trunk and panhypopituitarism: an autopsy case.

Tokushima M, Tago M, E Katsuki N, Yamashita S BMJ Case Rep. 2021; 14(3).

PMID: 33731406 PMC: 7978074. DOI: 10.1136/bcr-2020-239422.

Primary Pituitary Lymphoma in Immunocompetent Patients: A Report on Two Case Studies and the Review of Literature.

Duan L, Liu J, Zhang Y, Cui L, Zhai X, Pan B Front Endocrinol (Lausanne). 2021; 11:562850.

PMID: 33613443 PMC: 7890261. DOI: 10.3389/fendo.2020.562850.

Primary central nervous system lymphoma involving the hypothalamic-pituitary axis: a case series and pooled analysis.

Shin D, Kim J, Kim Y, Cho Y, Hong S J Neurooncol. 2020; 147(2):339-349.

PMID: 32221784 DOI: 10.1007/s11060-020-03422-x.

References

Helle T, Britt R, Colby T . Primary lymphoma of the central nervous system. Clinicopathological study of experience at Stanford. J Neurosurg. 1984; 60(1):94-103. DOI: 10.3171/jns.1984.60.1.0094. View

Sheehan T, Cuthbert R, Parker A . Central nervous system involvement in haematological malignancies. Clin Lab Haematol. 1989; 11(4):331-8. DOI: 10.1111/j.1365-2257.1989.tb00231.x. View

Freda P, Post K . Differential diagnosis of sellar masses. Endocrinol Metab Clin North Am. 1999; 28(1):81-117, vi. DOI: 10.1016/s0889-8529(05)70058-x. View

Kawakami Y, Tabuchi K, Ohnishi R, Asari S, Nishimoto A . Primary central nervous system lymphoma. J Neurosurg. 1985; 62(4):522-7. DOI: 10.3171/jns.1985.62.4.0522. View

McCormick P, Post K, Kandji A, Hays A . Metastatic carcinoma to the pituitary gland. Br J Neurosurg. 1989; 3(1):71-9. DOI: 10.3109/02688698909001028. View

Gottfredsson M, Oury T, Bernstein C, Carpenter C, Bartlett J . Lymphoma of the pituitary gland: an unusual presentation of central nervous system lymphoma in AIDS. Am J Med. 1996; 101(5):563-4. DOI: 10.1016/s0002-9343(96)00257-4. View

Masse S, Wolk R, Conklin R . Peripituitary gland involvement in acute leukemia in adults. Arch Pathol. 1973; 96(2):141-2. View

Sautner D, Saeger W, Ludecke D . Tumors of the sellar region mimicking pituitary adenomas. Exp Clin Endocrinol. 1993; 101(5):283-9. DOI: 10.1055/s-0029-1211245. View

Murray K, Kun L, Cox J . Primary malignant lymphoma of the central nervous system. Results of treatment of 11 cases and review of the literature. J Neurosurg. 1986; 65(5):600-7. DOI: 10.3171/jns.1986.65.5.0600. View

10.

Thodou E, Asa S, Kontogeorgos G, Kovacs K, Horvath E, Ezzat S . Clinical case seminar: lymphocytic hypophysitis: clinicopathological findings. J Clin Endocrinol Metab. 1995; 80(8):2302-11. DOI: 10.1210/jcem.80.8.7629223. View

11.

Cosman F, Post K, Holub D, Wardlaw S . Lymphocytic hypophysitis. Report of 3 new cases and review of the literature. Medicine (Baltimore). 1989; 68(4):240-56. DOI: 10.1097/00005792-198907000-00006. View

12.

Fine H, Mayer R . Primary central nervous system lymphoma. Ann Intern Med. 1993; 119(11):1093-104. DOI: 10.7326/0003-4819-119-11-199312010-00007. View

13.

Jho H . Endoscopic pituitary surgery. Pituitary. 2000; 2(2):139-54. DOI: 10.1023/a:1009991631761. View

14.

Singh V, Mahapatra A, Dinde A . Sellar-suprasellar primary malignant lymphoma: case report. Indian J Cancer. 1993; 30(2):88-91. View

15.

Sakakibara Y, Matsuzawa M, Taguchi Y, Sekino H, Shinagawa T, Abe M . [A case of sellar T cell type malignant lymphoma]. No Shinkei Geka. 1998; 26(1):53-8. View

16.

DUCHEN L, TREIP C . Microgliomatosis presenting with dementia and hypopituitarism. J Pathol. 1969; 98(2):143-6. DOI: 10.1002/path.1710980208. View