Alpha 2.0
Login Register
» Articles » PMID: 1107121

Immuno-fluorescent Reactivity to Anti-somatostatin in the Gastro-intestinal Mucosa of the Dog

Overview
Journal Diabetologia
Specialty Endocrinology
Date 1975 Aug 1
PMID 1107121
Citations 22
Authors
C Rufener
M P Dubois
F Malaisse Lagae
L Oric
Affiliations
Soon will be listed here.
Abstract

Evidence is presented that somatostatin-containing cells are present in the gastro-intestinal tract of the dog. Thus immuno-fluorescent cells were detected by the use of antiserum to cyclic somatostatin. These cells were mainly encountered in the antral mucosa and in the neighbourhood of gastrin-producing cells. No cross reaction was observed between gastrin and somatostatin. It is suggested that locally produced somatostatin controls gastrin secretion, and, more generally, that somatostatin-containing cells, multifocally distributed, modulates secretion of a large number of glands.

Citing Articles

Somatostatin and somatostatin receptor physiology.

Barnett P Endocrine. 2003; 20(3):255-64.

PMID: 12721505 DOI: 10.1385/ENDO:20:3:255.

The fine structure of the stomach mucosa of the Llama (Llama guanacoe). II. The fundic region of the hind stomach.

Luciano L, Reale E, von Engelhardt W Cell Tissue Res. 1980; 208(2):207-28.

PMID: 7407832 DOI: 10.1007/BF00234871.

Origin and development of VIP and substance P containing neurons in the embryonic avian gut.

Chanconie M, Polak J, Le Douarin N Histochemistry. 1981; 71(3):313-23.

PMID: 6167534 DOI: 10.1007/BF00495878.

Effect of somatostatin, secretin, and glucagon on secretagogue stimulated aminopyrine uptake in isolated canine parietal cells.

Perez-Reyes E, Payne N, Gerber J Agents Actions. 1983; 13(4):265-8.

PMID: 6137136 DOI: 10.1007/BF01971476.

Immunocytochemical localization of prosomatostatin fragments in maturing and mature secretory granules of pancreatic and gastrointestinal D cells.

Ravazzola M, Benoit R, Ling N, Guillemin R, Orci L Proc Natl Acad Sci U S A. 1983; 80(1):215-8.

PMID: 6130530 PMC: 393342. DOI: 10.1073/pnas.80.1.215.

References
1.
Yen S, Siler T, DeVane G . Effect of somatostatin in patients with acromegaly: suppression of growth hormone, prolactin, insulin and glucose levels. N Engl J Med. 1974; 290(17):935-8. DOI: 10.1056/NEJM197404252901704. View
2.
Creutzfeldt W, Lankisch P, Folsch U . [Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration (author's transl)]. Dtsch Med Wochenschr. 1975; 100(20):1135-8. View
3.
DOBBS R, Sakurai H, Sasaki H, Faloona G, Valverde I, Baetens D . Glucagon: role in the hyperglycemia of diabetes mellitus. Science. 1975; 187(4176):544-7. DOI: 10.1126/science.1089999. View
4.
Gerich J, Lorenzi M, Schneider V, Kwan C, KARAM J, Guillemin R . Inhibition of pancreatic glucagon responses to arginine by somatostatin in normal man and in insulin-dependent diabetics. Diabetes. 1974; 23(11):876-80. DOI: 10.2337/diab.23.11.876. View
5.
Dubois M . Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas. Proc Natl Acad Sci U S A. 1975; 72(4):1340-3. PMC: 432529. DOI: 10.1073/pnas.72.4.1340. View