RNA Polymerase Inhibitors with Activity Against Rifampin-resistant Mutants of Staphylococcus Aureus

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2000 Oct 19

PMID 11036042

Citations 33

Authors

A ONeill

B Oliva

C Storey

A Hoyle

C Fishwick

I Chopra

Affiliations

Soon will be listed here.

Abstract

A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase beta-subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.

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