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» Articles » PMID: 10991886

Bioavailability of Praziquantel Increases with Concomitant Administration of Food

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 2000 Sep 19
PMID 10991886
Citations 30
Authors
N Castro
R Medina
J Sotelo
H Jung
Affiliations
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Abstract

In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.

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