Mitochondrial DNA Heteroplasmy in Cloned Cattle Produced by Fetal and Adult Cell Cloning

Overview

Journal Nat Genet

Specialty Genetics

Date 2000 Jul 11

PMID 10888867

Citations 26

Authors

R Steinborn

P Schinogl

V Zakhartchenko

R Achmann

W Schernthaner

M Stojkovic

E Wolf

M Muller

G Brem

Affiliations

Soon will be listed here.

Abstract

Mammals have been cloned from adult donor cells. Here we report the first cases of mitochondrial DNA (mtDNA) heteroplasmy in adult mammalian clones generated from fetal and adult donor cells. The heteroplasmic clones included a healthy cattle equivalent of the sheep Dolly, for which a lack of heteroplasmy was reported.

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