Calcium, Vitamin D, Sunshine Exposure, Dairy Products and Colon Cancer Risk (United States)
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Objective: Epidemiologic studies on calcium, vitamin D and colon cancer are inconsistent, whereas experimental studies more regularly show a protective effect. To evaluate potential sources of inconsistencies, data from a large case-control study were analyzed, stratifying on potential effect modifiers.
Methods: Data were collected by certified interviewers in Northern California, Utah and Minnesota. Analyses included 1993 incident colon cancer cases and 2410 population-based controls. Multivariate logistic regression models included age, sex, BMI, family history, physical activity, intake of energy, dietary fiber, aspirin and NSAIDs.
Results: Dietary calcium was inversely associated with colon cancer risk in men (OR highest vs lowest quintile = 0.6, 95% CI = 0.5-0.9) and women (OR = 0.6, 95% CI = 0.4-0.9). No statistically significant associations were observed for dietary vitamin D or sunshine exposure. Consumption of total low-fat dairy products was associated with a statistically significantly decreased risk in men and women (ORs highest vs lowest category of intake = 0.8 and 0.7 respectively). Calcium supplement use was inversely associated with risk in both sexes (ORs use vs non-use = 0.8). Vitamin D supplements were inversely associated with risk in men (OR = 0.5) and women (OR = 0.6) but confidence limits included 1.0.
Conclusions: These data provide additional support of an inverse association between high levels of calcium intake and colon cancer risk.
Petre-Mandache B, Burada E, Cucu M, Atasie D, Riza A, Streata I Curr Oncol. 2024; 31(10):6406-6418.
PMID: 39451780 PMC: 11505952. DOI: 10.3390/curroncol31100476.
Dietary risk factors for colorectal cancer in Uganda: a case-control study.
Wismayer R, Kiwanuka J, Wabinga H, Odida M BMC Nutr. 2024; 10(1):88.
PMID: 38898481 PMC: 11186163. DOI: 10.1186/s40795-024-00894-2.
Fermented Dairy Food Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis.
Liang Z, Song X, Hu J, Wu R, Li P, Dong Z Front Oncol. 2022; 12:812679.
PMID: 35692761 PMC: 9174999. DOI: 10.3389/fonc.2022.812679.
Nam J, Koh M, Kang H, Ryu K, Lee D, Kim S Gut Liver. 2022; 16(2):269-276.
PMID: 35292606 PMC: 8924802. DOI: 10.5009/gnl210417.
Boughanem H, Canudas S, Hernandez-Alonso P, Becerra-Tomas N, Babio N, Salas-Salvado J Cancers (Basel). 2021; 13(11).
PMID: 34200111 PMC: 8201292. DOI: 10.3390/cancers13112814.