Antibody Response of C3H in Equilibrium (CKB X CWB)F1 Tetraparental Mice to Poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys Immunization

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1976 Jul 1

PMID 1084401

Citations 10

Authors

K B Bechtol

H O McDevitt

Affiliations

Soon will be listed here.

Abstract

To test whether the antigen-specific stimulation of low responder-genotype B cells in tetraparental mice is due to a histoincompatibility reaction (allogeneic effect) against these B cells, tetraparental mice were constructed (a) between an Ir-1A low responder to the antigen poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys. [(T,G)-A--L] and an Ir-1A F1 high responder and (b) between two histoincompatible Ir-lA low responders. In the first case the F1 high responder embryo shares the whole of the H-2 complex, including Ir, with the low responder embryo.

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