T and CR+ Lymphocyte Profile in Leprosy and the Effect of Treatment

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1976 Jan 1

PMID 1082444

Citations 7

Authors

R SHER

G Holm

S H Kok

H J Koornhof

A Glover

Affiliations

Soon will be listed here.

Abstract

Thymus-derived lymphocytes (T lymphocytes) and complement receptor-bearing lymphocytes (CR+ lymphocytes) were estimated by using erythrocyte rosettes and erythrocyte-antibody-complement rosettes as markers in untreated lepromatous and untreated tuberculoid patients and in healthy controls. Treated lepromatous cases were also investigated. Ten cases of untreated lepromatous patients were reassessed 6 months or more after therapy commenced. A significant decrease in both percentages and absolute numbers of CR+ cells in the untreated lepromatous leprosy subjects was observed. This decrease showed a return to normal levels after treatment. The percentage of T cells in the untreated lepromatous cases was normal; however, the absolute numbers of T cells and the total lymphocyte count showed a significant decrease. After therapy, the T cell population was unchanged but the total number of lymphocytes increased significantly with treatment. The absolute number of T and CR+ cells was significantly less in the untreated than in the treated lepromatous patients.

Citing Articles

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References

Mellstedt H, Holm G . In vitro studies of lymphocytes from patients with plasma cell myeloma. I. Stimulation by mitogens and cytotoxic activities. Clin Exp Immunol. 1973; 15(3):309-20. PMC: 1553898. View

Rojas-Espinosa O, Estrada-Parra S . Presence of C1q-reactive immune complexes in patients with leprosy. Clin Exp Immunol. 1972; 12(2):215-23. PMC: 1553577. View

Turk J, Waters M . Immunological significance of changes in lymph nodes across the leprosy spectrum. Clin Exp Immunol. 1971; 8(3):363-76. PMC: 1712922. View

Turk J, Bryceson A . Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971; 13:209-66. DOI: 10.1016/s0065-2776(08)60185-6. View

Han S, WEISER R, Lin Y . Transformation of leprous lymphocytes by leprolin, tuberculin and phytohemagglutinin. Int J Lepr Other Mycobact Dis. 1971; 39(4):789-95. View

BOYLE W . An extension of the 51Cr-release assay for the estimation of mouse cytotoxins. Transplantation. 1968; 6(6):761-4. DOI: 10.1097/00007890-196809000-00002. View

RIDLEY D, Jopling W . Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966; 34(3):255-73. View

Jondal M, Holm G, Wigzell H . Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972; 136(2):207-15. PMC: 2139198. DOI: 10.1084/jem.136.2.207. View

Moran C, RYDER G, Turk J, Waters M . Evidence for circulating immune complexes in lepromatous leprosy. Lancet. 1972; 2(7777):572-3. DOI: 10.1016/s0140-6736(72)91962-9. View

10.

Waldorf D, Sheagren J, TRAUTMAN J, Block J . Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet. 1966; 2(7467):773-6. DOI: 10.1016/s0140-6736(66)90366-7. View

11.

Rodriguez Paradisi E, De Bonaparte Y, MORGENFELD M . Blasts in lepromatous leprosy. Lancet. 1968; 1(7537):308-9. DOI: 10.1016/s0140-6736(68)90173-6. View

12.

Turk J, Waters M . Cell-mediated immunity in patients with leprosy. Lancet. 1969; 2(7614):243-6. DOI: 10.1016/s0140-6736(69)90009-9. View

13.

Dwyer J, Bullock W, FIELDS J . Disturbance of the blood T:B lymphocyte ratio in lepromatous leprosy. Clinical and immunologic correlations. N Engl J Med. 1973; 288(20):1036-9. DOI: 10.1056/NEJM197305172882002. View

14.

Lim S, Kiszkiss D, Jacobson R, Choi Y, GOOD R . Thymus-dependent lymphocytes of peripheral blood in leprosy patients. Infect Immun. 1974; 9(2):394-9. PMC: 414815. DOI: 10.1128/iai.9.2.394-399.1974. View

15.

Drutz D, Chen T, Lu W . The continuous bacteremia of lepromatous leprosy. N Engl J Med. 1972; 287(4):159-64. DOI: 10.1056/NEJM197207272870402. View

16.

Lim S, Jacobson R, GOOD R . B lymphocytes in lepromatous leprosy. N Engl J Med. 1973; 288(20):1033-5. DOI: 10.1056/NEJM197305172882001. View

17.

Playfair J . The role of antibody in T-cell responses. Clin Exp Immunol. 1974; 17(1):1-18. PMC: 1554067. View

18.

Godal T . Cellular immune defect in lepromatous leprosy. Ethiop Med J. 1973; 11(2):190-3. View