R-factor Mediated Beta-lactamase Production by Haemophilus Influenzae

Overview

Journal J Med Microbiol

Specialty Microbiology

Date 1975 Aug 1

PMID 1080810

Citations 20

Authors

R B Sykes

M Matthew

C H OCALLAGHAN

Affiliations

Soon will be listed here.

Abstract

Production of beta-lactamase by 15 strains of Haemophilus influenzae has been investigated. All the strains produce a constitutive beta-lactamase, which readily hydrolyses penicillin G, ampicillin, and cephaloridine. The beta-lactamase produced by these strains is indistinguishable from the type-IIIa enzyme commonly found in strains of Escherichia coli. The beta-lactamase gene has been transferred from the enzyme-producing strains of Haemophilus to strains of H. parainfluenzae and a strain of E. coli.

Citing Articles

Role of Horizontal Gene Transfer in the Development of Multidrug Resistance in Haemophilus influenzae.

Hegstad K, Mylvaganam H, Janice J, Josefsen E, Sivertsen A, Skaare D mSphere. 2020; 5(1).

PMID: 31996416 PMC: 6992377. DOI: 10.1128/mSphere.00969-19.

Carbapenem-Nonsusceptible Haemophilus influenzae with Penicillin-Binding Protein 3 Containing an Amino Acid Insertion.

Kitaoka K, Kimura K, Kitanaka H, Banno H, Jin W, Wachino J Antimicrob Agents Chemother. 2018; 62(8).

PMID: 29784853 PMC: 6105787. DOI: 10.1128/AAC.00671-18.

A cross-Canada surveillance of antimicrobial resistance in respiratory tract pathogens.

Davidson R, Low D Can J Infect Dis. 2012; 10(2):128-33.

PMID: 22346378 PMC: 3250720. DOI: 10.1155/1999/278586.

Determination of antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae and characterization of their beta-lactamases. Canadian Haemophilus Study Group.

Scriver S, Walmsley S, Kau C, Hoban D, Brunton J, McGeer A Antimicrob Agents Chemother. 1994; 38(7):1678-80.

PMID: 7979309 PMC: 284617. DOI: 10.1128/AAC.38.7.1678.

Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics.

Ogawara H Microbiol Rev. 1981; 45(4):591-619.

PMID: 7035856 PMC: 281529. DOI: 10.1128/mr.45.4.591-619.1981.