Simplification of the Clinical Phase of IVF and ICSI Treatment in Programmed Cycles

Overview

Journal Int J Gynaecol Obstet

Publisher Wiley

Specialty Gynecology & Obstetrics

Date 2000 May 10

PMID 10802081

Citations 5

Authors

V Vlaisavljevic

B Kovacic

V Gavric-Lovrec

M Reljic

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the success of a protocol for controlled ovarian hyperstimulation allowing patient self-selection into groups for ovulation stimulation planned 8 weeks and more in advance following cycle synchronization, drug self-administration as well as a reduced number of folliculometries.

Methods: A total of 714 patients received the same stimulation protocol. In 260 cases GnRH-a was applied daily and in 454 as depot. In all patients FSH-HP was self-administered subcutaneously for ovarian stimulation. In 316 patients IVF and in 398 patients ICSI was performed.

Results: The delivery rate per started cycle was higher in patients receiving depot GnRH-a in the IVF and ICSI group (30.2 vs. 23.4) than in those receiving subcutaneous GnRH-a (20.2 vs. 22.1).

Conclusion: Programming of the IVF/ICSI cycle greatly simplifies treatment. A comparison of pregnancy rate and delivery rate per cycle between depot and subcutaneous daily application of GnRh-a did not confirm any statistically significant difference.

Citing Articles

Effects of Different Exposure Days to Gonadotropin-Releasing Hormone Agonist (GnRH-a) on Live Birth Rates in the Depot GnRH-a Protocol: A Retrospective Analysis of 7007 Cycles.

Song J, Wu W, Jiang L, Duan C, Xu J Med Sci Monit. 2021; 27:e929854.

PMID: 33814548 PMC: 8034236. DOI: 10.12659/MSM.929854.

Maternal serum levels of angiogenic markers and markers of placentation in pregnancies conceived with fresh and vitrified-warmed blastocyst transfer.

Reljic M, Porovic A J Assist Reprod Genet. 2019; 36(7):1489-1495.

PMID: 31104293 PMC: 6642279. DOI: 10.1007/s10815-019-01484-z.

Endometrial injury, the quality of embryos, and blastocyst transfer are the most important prognostic factors for in vitro fertilization success after previous repeated unsuccessful attempts.

Reljic M, Knez J, Kovac V, Kovacic B J Assist Reprod Genet. 2017; 34(6):775-779.

PMID: 28386815 PMC: 5445053. DOI: 10.1007/s10815-017-0916-4.

What is the value of anti-Müllerian hormone in predicting the response to ovarian stimulation with GnRH agonist and antagonist protocols?.

Knez J, Kovacic B, Medved M, Vlaisavljevic V Reprod Biol Endocrinol. 2015; 13:58.

PMID: 26059906 PMC: 4470079. DOI: 10.1186/s12958-015-0049-5.

Human chorionic gonadotropin levels are equally predictive for pregnancy outcome after fresh and vitrified-warmed blastocyst transfer.

Reljic M, Knez J, Vlaisavljevic V J Assist Reprod Genet. 2013; 30(11):1459-63.

PMID: 24043384 PMC: 3879932. DOI: 10.1007/s10815-013-0099-6.