Interventions for Treating Genital Chlamydia Trachomatis Infection in Pregnancy

Overview

Journal Cochrane Database Syst Rev

Publisher Wiley

Specialties General Medicine
Health Services

Date 2000 May 5

PMID 10796106

Citations 18

Authors

P Brocklehurst

G Rooney

Affiliations

Soon will be listed here.

Abstract

Background: Chlamydia trachomatis is a sexually transmitted infection. Mother-to-child transmission can occur at the time of birth and may result in ophthalmia neonatorum or pneumonitis in the newborn.

Objectives: The objective of this review was to assess the effects of antibiotics in the treatment of genital infection with Chlamydia trachomatis during pregnancy with respect to neonatal and maternal morbidity.

Search Strategy: We searched the Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register (Cochrane Library issue 1, 1999).

Selection Criteria: Randomised trials of any antibiotic regimen compared with placebo or no treatment or alternative antibiotic regimens in pregnant women with genital Chlamydia trachomatis infection.

Data Collection And Analysis: Trial quality assessments and data extraction were done independently by two reviewers. Study authors were contacted for additional information.

Main Results: Eleven trials were included. Trial quality was generally good. Amoxycillin appeared to be as effective as erythromycin in achieving microbiological cure (odds ratio 0.54, 95% confidence interval 0.28 to 1.02). Amoxycillin was better tolerated than erythromycin (odds ratio 0.16, 95% confidence interval 0.09 to 0.30). Clindamycin and azithromycin also appear to be effective, although the numbers of women included in trials are small.

Reviewer's Conclusions: Amoxycillin appears to be an acceptable alternative therapy for the treatment of genital chlamydial infections in pregnancy when compared with erythromycin. Clindamycin and azithromycin may be considered if erythromycin and amoxycillin are contra-indicated or not tolerated.

Citing Articles

The global prevalence of Chlamydia trachomatis genital infection in pregnant women: a meta-analysis.

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Screening and Treatment in Pregnancy to Reduce Adverse Pregnancy and Neonatal Outcomes: A Review.

Adachi K, Nielsen-Saines K, Klausner J Front Public Health. 2021; 9:531073.

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Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB).

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Chlamydia trachomatis and Adverse Pregnancy Outcomes: Meta-analysis of Patients With and Without Infection.

Olson-Chen C, Balaram K, Hackney D Matern Child Health J. 2018; 22(6):812-821.

PMID: 29417367 DOI: 10.1007/s10995-018-2451-z.

Interventions for treating genital Chlamydia trachomatis infection in pregnancy.

Cluver C, Novikova N, Eriksson D, Bengtsson K, Lingman G Cochrane Database Syst Rev. 2017; 9:CD010485.

PMID: 28937705 PMC: 6483758. DOI: 10.1002/14651858.CD010485.pub2.

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