Intra-articular IL-10 Gene Transfer Regulates the Expression of Collagen-induced Arthritis (CIA) in the Knee and Ipsilateral Paw

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2000 May 3

PMID 10792391

Citations 27

Authors

E Lubberts

L A Joosten

L van den Bersselaar

M M Helsen

A C Bakker

Z Xing

C D Richards

W B van den Berg

Affiliations

Soon will be listed here.

Abstract

We studied the effects of local IL-10 application, introduced by a recombinant human type 5 adenovirus vector, in the mouse knee joint during the early phase of CIA. One intra-articular injection with the IL-10-expressing virus (Ad5E1mIL-10) caused substantial over-expression of IL-10 in the mouse knee joint, using virus dosages which did not induce distracting inflammation. High expression of IL-10 was noted for a few days, being maximal at day 1. One intra-articular injection of Ad5E1mIL-10 in the knee joints of collagen type II (CII)-immunized mice, before onset of CIA was noted, reduced the incidence of collagen arthritis in that knee. Of high interest, the protective effect of local IL-10 expression by Ad5E1mIL-10 was not restricted to the knee joint alone. The arthritis incidence in the ipsilateral paw was highly suppressed. In contrast, local IL-10 over-expression was not effective when treatment was started after onset of CIA. Further analysis in the acute streptococcal cell wall-induced arthritis model revealed that local IL-10 over-expression markedly suppressed the production of tumour necrosis factor-alpha (TNF-alpha) and IL-1alpha, but had no significant effect on IL-1beta and IL-12 production in the inflamed synovium. These data indicate that local over-expression of IL-10 in the knee joint of mice regulates the expression of collagen arthritis, probably through down-regulation of TNF-alpha.

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References

Fiorentino D, Bond M, Mosmann T . Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989; 170(6):2081-95. PMC: 2189521. DOI: 10.1084/jem.170.6.2081. View

Elliott M, Maini R, Feldmann M, Kalden J, Antoni C, Smolen J . Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet. 1994; 344(8930):1105-10. DOI: 10.1016/s0140-6736(94)90628-9. View

Stuart J, Townes A, Kang A . Collagen autoimmune arthritis. Annu Rev Immunol. 1984; 2:199-218. DOI: 10.1146/annurev.iy.02.040184.001215. View

van den Broek M, van den Berg W, van de Putte L, Severijnen A . Streptococcal cell wall-induced arthritis and flare-up reaction in mice induced by homologous or heterologous cell walls. Am J Pathol. 1988; 133(1):139-49. PMC: 1880648. View

Firestein G, Alvaro-Gracia J, Maki R, ALVARO-GARCIA J . Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol. 1990; 144(9):3347-53. View

Bucala R, Ritchlin C, Winchester R, Cerami A . Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts. J Exp Med. 1991; 173(3):569-74. PMC: 2118837. DOI: 10.1084/jem.173.3.569. View

Holmdahl R, Andersson M, Goldschmidt T, Gustafsson K, Jansson L, Mo J . Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev. 1990; 118:193-232. DOI: 10.1111/j.1600-065x.1990.tb00817.x. View

Moore K, OGarra A, de Waal Malefyt R, Vieira P, Mosmann T . Interleukin-10. Annu Rev Immunol. 1993; 11:165-90. DOI: 10.1146/annurev.iy.11.040193.001121. View

Chen E, Keystone E, Fish E . Restricted cytokine expression in rheumatoid arthritis. Arthritis Rheum. 1993; 36(7):901-10. DOI: 10.1002/art.1780360706. View

10.

Roessler B, ALLEN E, Wilson J, Hartman J, Davidson B . Adenoviral-mediated gene transfer to rabbit synovium in vivo. J Clin Invest. 1993; 92(2):1085-92. PMC: 294950. DOI: 10.1172/JCI116614. View

11.

Llorente L, Richaud-Patin Y, Fior R, Alcocer-Varela J, Wijdenes J, Fourrier B . In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. A potential mechanism of B lymphocyte hyperactivity and autoimmunity. Arthritis Rheum. 1994; 37(11):1647-55. DOI: 10.1002/art.1780371114. View

12.

Cush J, Splawski J, Thomas R, McFarlin J, Schulze-Koops H, Davis L . Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis Rheum. 1995; 38(1):96-104. DOI: 10.1002/art.1780380115. View

13.

Chomarat P, Vannier E, Dechanet J, Rissoan M, Banchereau J, Dinarello C . Balance of IL-1 receptor antagonist/IL-1 beta in rheumatoid synovium and its regulation by IL-4 and IL-10. J Immunol. 1995; 154(3):1432-9. View

14.

Arend W, Dayer J . Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum. 1995; 38(2):151-60. DOI: 10.1002/art.1780380202. View

15.

Wang P, Wu P, Siegel M, Egan R, Billah M . Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem. 1995; 270(16):9558-63. DOI: 10.1074/jbc.270.16.9558. View

16.

Kasama T, Strieter R, Lukacs N, Lincoln P, Burdick M, Kunkel S . Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest. 1995; 95(6):2868-76. PMC: 295974. DOI: 10.1172/JCI117993. View

17.

Roessler B, Hartman J, VALLANCE D, Latta J, Janich S, Davidson B . Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector. Hum Gene Ther. 1995; 6(3):307-16. DOI: 10.1089/hum.1995.6.3-307. View

18.

Rankin E, Choy E, Kassimos D, Kingsley G, Sopwith A, Isenberg D . The therapeutic effects of an engineered human anti-tumour necrosis factor alpha antibody (CDP571) in rheumatoid arthritis. Br J Rheumatol. 1995; 34(4):334-42. DOI: 10.1093/rheumatology/34.4.334. View

19.

Cohen S, Katsikis P, Chu C, Thomssen H, Webb L, Maini R . High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane. Arthritis Rheum. 1995; 38(7):946-52. DOI: 10.1002/art.1780380710. View

20.

Drenth J, van Uum S, van Deuren M, Pesman G, van der Ven-Jongekrijg J, van der Meer J . Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production. J Appl Physiol (1985). 1995; 79(5):1497-503. DOI: 10.1152/jappl.1995.79.5.1497. View