Structure and Function of Interleukin-22 and Other Members of the Interleukin-10 Family

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2010 May 11

PMID 20454917

Citations 16

Authors

Daniela Barretto Barbosa Trivella

Jose Ribamar Ferreira-Junior

Laure Dumoutier

Jean-Christophe Renauld

Igor Polikarpov

Affiliations

Soon will be listed here.

Abstract

The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-lambdas (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric complexes. Upon interleukin/receptor complex formation, these proteins switch on the Jak/STAT pathway and elicit pleiotropic biological responses whose variety sharply contrasts with their structural similarities. IL-10 family members are involved in several human diseases and health conditions and hence their structural analyses may provide valuable information to design specific therapeutic strategies. In this review, we describe the human interleukin-10 family of cytokines, focusing on their structures and functions, with particular attention given to IL-22 and IL-10. We report on the recently published structures of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin physiology and physiopathology.

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