Antituberculosis Activity of Certain Antifungal and Antihelmintic Drugs

Overview

Journal Tuber Lung Dis

Specialty Pulmonary Medicine

Date 2000 Mar 9

PMID 10707260

Citations 35

Authors

Z Sun

Y Zhang

Affiliations

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Abstract

A panel of antifungal and antihelmintic drugs was tested for activity against Mycobacterium tuberculosis in vitro. Antifungal drugs, miconazole, 2-nitroimidazole, clotrimazole, and the antihelmintic drug niclosamide were found to have significant antituberculosis activity, with minimal inhibitory concentrations (MICs) between 1 and 10 micrograms/ml. Niclosamide and 2-nitroimidazole also had activity against stationary phase tubercle bacilli. Further testing of these drugs and their derivatives in vitro and in vivo appears to be warranted.

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