Measurement of Human Plasma Motilin

Overview

Journal Scand J Gastroenterol Suppl

Publisher Informa Healthcare

Specialty Gastroenterology

Date 1976 Jan 1

PMID 1069363

Citations 24

Authors

S R Bloom

P Mitznegg

M G Bryant

Affiliations

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Abstract

A specific radioimmunoassay has been developed for human plasma motilin. No cross reaction was seen with other gut hormones and only a single major peak of motilin immunoreactivity was found in plasma and gut extracts after gel chromatography. The motilin content of the human duodenum was 165.7+/-15.9 pmol/g wet weight and jejunum 37.5+/-2.8 pmol/g with negligible amounts in the rest of the gut. Fasting plasma motilin concentrations in 100 healthy subjects ranged from less than 5 to 300 pmol/l (mean 72 pmol/l).

Citing Articles

Effects of somatostatin prophylaxis after pylorus-preserving pancreaticoduodenectomy: increased delayed gastric emptying and reduced plasma motilin.

Shan Y, Sy E, Tsai M, Tang L, Li P, Lin P World J Surg. 2005; 29(10):1319-24.

PMID: 16284796 DOI: 10.1007/s00268-005-7943-5.

Pharmacokinetic and pharmacodynamic studies of SK-896, a new human motilin analogue, in healthy male volunteers.

Furuta Y, Nakayama Y, Nakashima M, Suzuki Y Clin Pharmacokinet. 2003; 42(6):575-84.

PMID: 12793841 DOI: 10.2165/00003088-200342060-00006.

Plasma motilin, gastrin, and enteroglucagon and feeding in the human newborn.

Lucas A, Adrian T, Christofides N, Bloom S, Aynsley-Green A Arch Dis Child. 1980; 55(9):673-7.

PMID: 7436530 PMC: 1627011. DOI: 10.1136/adc.55.9.673.

Separation of the gut hormone endocrine-cell storage granules of human jejunum using analytical subcellular fractionation.

Bryant M, Dawson J, Bloom S, Peters T Gut. 1980; 21(3):177-80.

PMID: 7399317 PMC: 1420354. DOI: 10.1136/gut.21.3.177.

Gut-hormone profile in totally pancreatectomised patients.

Dammann H, Besterman H, Bloom S, SCHREIBER H Gut. 1981; 22(2):103-7.

PMID: 7215941 PMC: 1419224. DOI: 10.1136/gut.22.2.103.