The Hippocampal Neurons of Neuronal Apoptosis Inhibitory Protein 1 (NAIP1)-deleted Mice Display Increased Vulnerability to Kainic Acid-induced Injury

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2000 Feb 19

PMID 10681452

Citations 20

Authors

M Holcik

C S Thompson

Z Yaraghi

C A Lefebvre

A E Mackenzie

R G Korneluk

Affiliations

Soon will be listed here.

Abstract

The neuronal apoptosis inhibitory protein (NAIP) is a member of a novel family of inhibitor of apoptosis (IAP) proteins. The IAP genes are highly conserved from baculovirus to metazoans and suppress apoptosis induced by a variety of triggers both in vitro and in vivo. Here we describe the generation and characterization of mice with the targeted deletion of NAIP1. We demonstrate that the NAIP1-deleted mice develop normally. However, the survival of pyramidal neurons in the hippocampus after kainic acid-induced limbic seizures is greatly reduced in the NAIP1 knock-out animals. Thus, although NAIP1 is not necessary for normal development of murine central nervous system, the endogenous NAIP1 is required for neuronal survival in pathological conditions.

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References

Morrison R, Wenzel H, Kinoshita Y, Robbins C, Donehower L, Schwartzkroin P . Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J Neurosci. 1996; 16(4):1337-45. PMC: 6578556. View

Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Farahani R . Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature. 1996; 379(6563):349-53. DOI: 10.1038/379349a0. View

Xu D, Korneluk R, Tamai K, Wigle N, Hakim A, MacKenzie A . Distribution of neuronal apoptosis inhibitory protein-like immunoreactivity in the rat central nervous system. J Comp Neurol. 1997; 382(2):247-59. View

Lefebvre S, Burlet P, Liu Q, Bertrandy S, Clermont O, Munnich A . Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet. 1997; 16(3):265-9. DOI: 10.1038/ng0797-265. View

Deveraux Q, Takahashi R, Salvesen G, Reed J . X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997; 388(6639):300-4. DOI: 10.1038/40901. View

Xu D, Crocker S, Doucet J, St-Jean M, Tamai K, Hakim A . Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. Nat Med. 1997; 3(9):997-1004. DOI: 10.1038/nm0997-997. View

Roy N, Deveraux Q, Takahashi R, Salvesen G, Reed J . The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1998; 16(23):6914-25. PMC: 1170295. DOI: 10.1093/emboj/16.23.6914. View

Seshagiri S, Miller L . Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1. Proc Natl Acad Sci U S A. 1998; 94(25):13606-11. PMC: 28353. DOI: 10.1073/pnas.94.25.13606. View

Lerma J . Kainate reveals its targets. Neuron. 1998; 19(6):1155-8. DOI: 10.1016/s0896-6273(00)80407-9. View

10.

Savitz S, ROSENBAUM D . Apoptosis in neurological disease. Neurosurgery. 1998; 42(3):555-72; discussion 573-4. DOI: 10.1097/00006123-199803000-00026. View

11.

Takahashi R, Deveraux Q, Tamm I, Welsh K, Salvesen G, Reed J . A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem. 1998; 273(14):7787-90. DOI: 10.1074/jbc.273.14.7787. View

12.

Yaraghi Z, Korneluk R, MacKenzie A . Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein). Genomics. 1998; 51(1):107-13. DOI: 10.1006/geno.1998.5378. View

13.

Hashimoto K, Watanabe K, Nishimura T, Iyo M, Shirayama Y, Minabe Y . Behavioral changes and expression of heat shock protein hsp-70 mRNA, brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acid. Brain Res. 1998; 804(2):212-23. DOI: 10.1016/s0006-8993(98)00708-2. View

14.

Hu R, Koh S, Torgerson T, Cole A . Neuronal stress and injury in C57/BL mice after systemic kainic acid administration. Brain Res. 1998; 810(1-2):229-40. DOI: 10.1016/s0006-8993(98)00863-4. View

15.

Gambardella A, Mazzei R, Toscano A, Annesi G, Pasqua A, Annesi F . Spinal muscular atrophy due to an isolated deletion of exon 8 of the telomeric survival motor neuron gene. Ann Neurol. 1998; 44(5):836-9. DOI: 10.1002/ana.410440522. View

16.

LaCasse E, Baird S, Korneluk R, Mackenzie A . The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene. 1999; 17(25):3247-59. DOI: 10.1038/sj.onc.1202569. View

17.

Deveraux Q, Reed J . IAP family proteins--suppressors of apoptosis. Genes Dev. 1999; 13(3):239-52. DOI: 10.1101/gad.13.3.239. View

18.

Becker A, Gillardon F, Blumcke I, Langendorfer D, Beck H, Wiestler O . Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus. Brain Res Mol Brain Res. 1999; 67(1):172-6. DOI: 10.1016/s0169-328x(99)00060-1. View

19.

Faherty C, Xanthoudakis S, Smeyne R . Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment. Brain Res Mol Brain Res. 1999; 70(1):159-63. DOI: 10.1016/s0169-328x(99)00143-6. View

20.

Yaraghi Z, Diez E, Gros P, MacKenzie A . cDNA cloning and the 5'genomic organization of Naip2, a candidate gene for murine Legionella resistance. Mamm Genome. 1999; 10(7):761-3. DOI: 10.1007/s003359901087. View