Integrin-like Proteins in Candida Spp. and Other Microorganisms

Overview

Journal Fungal Genet Biol

Specialties Biology
Genetics
Microbiology

Date 2000 Feb 12

PMID 10669579

Citations 14

Authors

M K Hostetter

Affiliations

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Abstract

The vertebrate integrins provide a paradigm for cell surface proteins involved in adhesion and morphogenesis. However, homologs of integrins have been found in more primitive organisms. This review will discuss the evidence for surface proteins in Candida albicans and Candida tropicalis that contain motifs reminiscent of integrins and will analyze the contributions of one of these proteins, Int1p, to adhesion, morphogenesis, and virulence. Other microorganisms thought to express integrin-like proteins will also be addressed.

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