[Pharmakokinetics of Hydroxy-urea. Therapy of Acute Myeoblastic Leukemias Using Synchronization and Recruitment Effects (author' Transl)]

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1976 Mar 1

PMID 1062636

Citations 5

Authors

H Sauer

R Pelka

W Wilmanns

Affiliations

Soon will be listed here.

Abstract

By a plasma-concentration of hydroxy-urea (HU) higher than 0.5-2.2x10(-4)M the DNA-synthesis in leukemia cells was blocked reversibly in 9 patients. The plasma half-time of HU varied between 120 and 198 min. To synchronize leukemic cell populations the DNS-synthesis was blocked over a period of 36 hours by maintaining the HU-concentration above the critical lower level. In a second phase-specific therapeutic step cytosine-arabinoside (AraC) was given 4 times in a dose of 1 mg/kg each. A recruitment after the application of AarC made more cells available for the next following synchronization step. 4 acute myeloblastic leukemias with high peripheral cell counts were treated according to this schedule. One patient is still in complete remission for now 14 month. This synchronization/recruitment schedule seems to be successful in acute myeloblastic leukemias with high proliferation rates measured by biochemical and cytokinetic methods.

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