Paraflagellar Rod Proteins Administered with Alum and IL-12 or Recombinant Adenovirus Expressing IL-12 Generates Antigen-specific Responses and Protective Immunity in Mice Against Trypanosoma Cruzi
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Successful vaccination of mice against an otherwise lethal challenge with the Peru strain of Trypanosoma cruzi necessitates the induction of a strong cell mediated immune response. Previously, immunization of mice with the paraflagellar rod proteins from Trypanosoma cruzi90% reduction in parasitemia in immunized mice challenged with the bloodstream stage of Trypanosoma cruzi.
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