The Macrophage in Chronic Obstructive Pulmonary Disease

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 1999 Nov 11

PMID 10556166

Citations 128

Authors

S D Shapiro

Affiliations

Soon will be listed here.

Abstract

Macrophages are the predominant defense cell in the normal lung and during conditions associated with chronic inflammation such as COPD. However, the role of the macrophage in the development of COPD has been controversial. Scientific evidence from a variety of sources is emerging that supports a primary role for the macrophage in regulating the inflammatory response and tissue destruction associated with COPD. The role of macrophage proteinases in the development of emphysema, a major component of COPD, will be discussed. Shapiro SD. The macrophage in chronic obstructive pulmonary disease.

Citing Articles

Single cell transcriptomics in blood of patients with chronic obstructive pulmonary disease.

Heo Y, Kim J, Hong S, Kim W BMC Pulm Med. 2025; 25(1):19.

PMID: 39810158 PMC: 11734329. DOI: 10.1186/s12890-024-03475-y.

Macrophages and the microbiome in chronic obstructive pulmonary disease.

Sandhu K, Scott A, Tatler A, Belchamber K, Cox M Eur Respir Rev. 2024; 33(174).

PMID: 39631929 PMC: 11615662. DOI: 10.1183/16000617.0053-2024.

Korean Red Ginseng suppresses emphysematous lesions induced by cigarette smoke condensate through inhibition of macrophage-driven apoptosis pathways.

Kim J, Kim J, Kim C, Jeong J, Ko J, Kim T J Ginseng Res. 2024; 48(2):181-189.

PMID: 38465217 PMC: 10920012. DOI: 10.1016/j.jgr.2023.11.001.

Protease-armed, Pathogenic Extracellular Vesicles Link Smoking and Chronic Obstructive Pulmonary Disease.

Madison M, Margaroli C, Genschmer K, Russell D, Wells J, Sari E Am J Respir Crit Care Med. 2023; 208(10):1115-1125.

PMID: 37713301 PMC: 10867940. DOI: 10.1164/rccm.202303-0471OC.

The Role of Smoking in the Mechanisms of Development of Chronic Obstructive Pulmonary Disease and Atherosclerosis.

Kotlyarov S Int J Mol Sci. 2023; 24(10).

PMID: 37240069 PMC: 10217854. DOI: 10.3390/ijms24108725.