Paired Moving Charge Model of Energy Coupling. III. Intrinsic Ionophores in Energy Coupling Systems

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1975 Mar 1

PMID 1055388

Citations 4

Authors

D E Green

G Blondin

R Kessler

J H Southard

Affiliations

Soon will be listed here.

Abstract

The experimental basis for the postulated role of intrinsic ionophores in mitochondrial ion transport and energy coupling is summarized. Intrinsic ionophores appear to be linked to, or contained within, specific ionophoroproteins localized in the inner membrane, and the isolation of these ionophores requires their release from the ionophoroproteins. At least ten different species of ionophores have been isolated from the mitochondrion, five of which have been wholly or in part chemically identified. Intrinsic ionophores have been implicated in the activation of inorganic phosphate in ATP synthesis and hydrolysis, and in the contol of the coupling modes. The presence of ionophores in soluble proteins such as troponin and in ATP-energized kinases has been demonstrated.

Citing Articles

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Physical basis of charge pairing in mitochondria.

Kemeny G, Singer P Proc Natl Acad Sci U S A. 1975; 72(6):2058-9.

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Isolation of an electrogenic K+/Ca2+ ionophore from an ionophoroprotein of beef heart mitochondria.

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Isolation of a low molecular weight Ca2+ carrier from calf heart inner mitochondrial membrane.

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