Odor Space and Olfactory Processing: Collective Algorithms and Neural Implementation

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1999 Oct 27

PMID 10535952

Citations 35

Authors

J J Hopfield

Affiliations

Soon will be listed here.

Abstract

Several basic olfactory tasks must be solved by highly olfactory animals, including background suppression, multiple object separation, mixture separation, and source identification. The large number N of classes of olfactory receptor cells-hundreds or thousands-permits the use of computational strategies and algorithms that would not be effective in a stimulus space of low dimension. A model of the patterns of olfactory receptor responses, based on the broad distribution of olfactory thresholds, is constructed. Representing one odor from the viewpoint of another then allows a common description of the most important basic problems and shows how to solve them when N is large. One possible biological implementation of these algorithms uses action potential timing and adaptation as the "hardware" features that are responsible for effective neural computation.

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References

Laurent G, Wehr M, Davidowitz H . Temporal representations of odors in an olfactory network. J Neurosci. 1996; 16(12):3837-47. PMC: 6578619. View

Stopfer M, Bhagavan S, Smith B, Laurent G . Impaired odour discrimination on desynchronization of odour-encoding neural assemblies. Nature. 1997; 390(6655):70-4. DOI: 10.1038/36335. View

Anderson P . More is different. Science. 1972; 177(4047):393-6. DOI: 10.1126/science.177.4047.393. View

Gray C, Singer W . Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex. Proc Natl Acad Sci U S A. 1989; 86(5):1698-702. PMC: 286768. DOI: 10.1073/pnas.86.5.1698. View

Gray C, Konig P, Engel A, Singer W . Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties. Nature. 1989; 338(6213):334-7. DOI: 10.1038/338334a0. View

Malnic B, Hirono J, Sato T, Buck L . Combinatorial receptor codes for odors. Cell. 1999; 96(5):713-23. DOI: 10.1016/s0092-8674(00)80581-4. View

Pevsner J, Trifiletti R, Strittmatter S, Snyder S . Isolation and characterization of an olfactory receptor protein for odorant pyrazines. Proc Natl Acad Sci U S A. 1985; 82(9):3050-4. PMC: 397704. DOI: 10.1073/pnas.82.9.3050. View

LAND E . COLOR VISION AND THE NATURAL IMAGE PART II. Proc Natl Acad Sci U S A. 1959; 45(4):636-44. PMC: 222609. DOI: 10.1073/pnas.45.4.636. View

Kauer J . Contributions of topography and parallel processing to odor coding in the vertebrate olfactory pathway. Trends Neurosci. 1991; 14(2):79-85. DOI: 10.1016/0166-2236(91)90025-p. View

10.

Hopfield J . Pattern recognition computation using action potential timing for stimulus representation. Nature. 1995; 376(6535):33-6. DOI: 10.1038/376033a0. View

11.

Hopfield J . Transforming neural computations and representing time. Proc Natl Acad Sci U S A. 1996; 93(26):15440-4. PMC: 26423. DOI: 10.1073/pnas.93.26.15440. View

12.

Lancet D . Vertebrate olfactory reception. Annu Rev Neurosci. 1986; 9:329-55. DOI: 10.1146/annurev.ne.09.030186.001553. View

13.

MacLeod K, Backer A, Laurent G . Who reads temporal information contained across synchronized and oscillatory spike trains?. Nature. 1998; 395(6703):693-8. DOI: 10.1038/27201. View

14.

Buck L, Axel R . A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 1991; 65(1):175-87. DOI: 10.1016/0092-8674(91)90418-x. View

15.

Potter H, Chorover S . Response plasticity in hamster olfactory bulb: peripheral and central processes. Brain Res. 1976; 116(3):417-29. DOI: 10.1016/0006-8993(76)90490-x. View

16.

Buck L . Information coding in the vertebrate olfactory system. Annu Rev Neurosci. 1996; 19:517-44. DOI: 10.1146/annurev.ne.19.030196.002505. View

17.

Sicard G, Holley A . Receptor cell responses to odorants: similarities and differences among odorants. Brain Res. 1984; 292(2):283-96. DOI: 10.1016/0006-8993(84)90764-9. View

18.

Stone H, BOSLEY J . OLFACTORY DISCRIMINATION AND WEBER'S LAW. Percept Mot Skills. 1965; 20:657-65. DOI: 10.2466/pms.1965.20.2.657. View

19.

Cain W . Differential sensitivity for smell: "noise" at the nose. Science. 1977; 195(4280):796-8. DOI: 10.1126/science.836592. View