T Helper 1- and T Helper 2-type Cytokine Imbalance in Pregnant Women with Pre-eclampsia

Overview

Journal Eur J Obstet Gynecol Reprod Biol

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 1999 Oct 6

PMID 10509785

Citations 30

Authors

D Darmochwal-Kolarz

B Leszczynska-Gorzelak

J Rolinski

J Oleszczuk

Affiliations

Soon will be listed here.

Abstract

Objectives: The purpose of our study was to investigate T helper 1/T helper 2 balance in pregnant women with pre-eclampsia.

Study Design: 18 patients with pre-eclampsia and 20 healthy pregnant women were included in the study. Peripheral blood mononuclear cells (PBMC) were stimulated with phytohaemagglutinin (PHA) for 48 h. Cytokine: interleukin-2 (11-2), interferon-gamma (IFN-gamma) and interleukin-10 (I1-10) concentrations in culture supernatants were determined using the ELISA method. Statistical analysis was performed using a standard non-parametric Mann-Whitney U-test.

Results: We found that in pre-eclamptic patients PHA-stimulated 11-2 and IFN-y production was significantly higher (P<0.001) and I1-10 production significantly lower (P<0.005) in comparison with the control group.

Conclusion: These results could suggest that there is Th1/Th2 imbalance in pre-eclamptic patients with predominant Th1-type immunity.

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